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Effect of Aldosterone-Producing Adenoma on Endothelial Function and Rho-Associated Kinase Activity in Patients With Primary Aldosteronism

The purpose of this study was to evaluate vascular function and activity of Rho-associated kinases (ROCKs) in patients with primary aldosteronism. Vascular function, including flow-mediated vasodilation (FMD) and nitroglycerine-induced vasodilation, and ROCK activity in peripheral leukocytes were ev...

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Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2015-04, Vol.65 (4), p.841-848
Main Authors: Matsumoto, Takeshi, Oki, Kenji, Kajikawa, Masato, Nakashima, Ayumu, Maruhashi, Tatsuya, Iwamoto, Yumiko, Iwamoto, Akimichi, Oda, Nozomu, Hidaka, Takayuki, Kihara, Yasuki, Kohno, Nobuoki, Chayama, Kazuaki, Goto, Chikara, Aibara, Yoshiki, Noma, Kensuke, Liao, James K, Higashi, Yukihito
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Language:English
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Summary:The purpose of this study was to evaluate vascular function and activity of Rho-associated kinases (ROCKs) in patients with primary aldosteronism. Vascular function, including flow-mediated vasodilation (FMD) and nitroglycerine-induced vasodilation, and ROCK activity in peripheral leukocytes were evaluated in 21 patients with aldosterone-producing adenoma (APA), 23 patients with idiopathic hyperaldosteronism (IHA), and 40 age-, sex-, and blood pressure–matched patients with essential hypertension (EHT). FMD was significantly lower in the APA group than in the IHA and EHT groups (3.2±2.0% versus 4.6±2.3% and 4.4±2.2%; P
ISSN:0194-911X
1524-4563
DOI:10.1161/HYPERTENSIONAHA.114.05001