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Exercise improves endothelial function: A local analysis of production of nitric oxide and reactive oxygen species

This study aimed at investigating the acute effects of aerobic exercise on endothelium-dependent vasomotor function of rat aorta, as well as mechanisms involved in endothelial nitric oxide (NO) bioactivity. Wistar rats were assigned to either a resting control (C, n = 21) or acutely exercised (E, n ...

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Published in:Nitric oxide 2015-02, Vol.45, p.7-14
Main Authors: Tanaka, Leonardo Yuji, Bechara, Luiz Roberto Grassmann, dos Santos, Adriana Marques, Jordão, Camila Paixão, de Sousa, Luís Gustavo Oliveira, Bartholomeu, Teresa, Ventura, Laura Inês, Laurindo, Francisco Rafael Martins, Ramires, Paulo Rizzo
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Language:English
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Summary:This study aimed at investigating the acute effects of aerobic exercise on endothelium-dependent vasomotor function of rat aorta, as well as mechanisms involved in endothelial nitric oxide (NO) bioactivity. Wistar rats were assigned to either a resting control (C, n = 21) or acutely exercised (E, n = 21) groups (60 min, 55–60% of maximum speed). After exercise, thoracic aorta was excised and cut into rings. Two rings were promptly applied to evaluate vasomotor function and the rest of aorta was used for additional measurements. Acute exercise significantly improved maximum ACh-induced relaxation (C, 91.6 ± 1.2 vs. E, 102.4 ± 1.7%, p 
ISSN:1089-8603
1089-8611
DOI:10.1016/j.niox.2015.01.003