Living Donor Liver Transplantation: A Life-Saving Option in Emergency Situations for Diffuse Hepatic Neuroendocrine Tumor Metastasis

Abstract Liver metastasis is the main cause of death in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs), but only 10%–20% of metastasis in these cases is resectable at the time of diagnosis. In some cases, medical and interventional radiological treatments may not be effective....

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Bibliographic Details
Published in:Transplantation proceedings 2015-03, Vol.47 (2), p.427-430
Main Authors: Yankol, Y, Mecit, N, Kanmaz, T, Acarli, K, Kalayoglu, M
Format: Article
Language:English
Subjects:
Adult
Emergencies
Fatal Outcome
Female
Humans
Intestinal Neoplasms - secondary
Intestinal Neoplasms - surgery
Liver Neoplasms - secondary
Liver Neoplasms - surgery
Liver Transplantation - methods
Living Donors
Middle Aged
Neuroendocrine Tumors - secondary
Neuroendocrine Tumors - surgery
Pancreatic Neoplasms - secondary
Pancreatic Neoplasms - surgery
Stomach Neoplasms - secondary
Stomach Neoplasms - surgery
Surgery
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Summary:Abstract Liver metastasis is the main cause of death in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs), but only 10%–20% of metastasis in these cases is resectable at the time of diagnosis. In some cases, medical and interventional radiological treatments may not be effective. Liver transplantation, although controversial, may be an option. Worldwide organ-sharing systems do not provide exception points, but give recommendations for liver transplantation in cases of hepatic metastasis from GEP-NETs due to the issue of fair access to donor organs. Living donor liver transplantation is an option in select cases. Presented here are 2 cases in which living donor liver transplantation was performed in emergency situations as a life-saving procedure, with acceptable survival and without donor complications.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2014.12.017