Hippocampal serotonin depletion is related to the presence of generalized tonic–clonic seizures, but not to psychiatric disorders in patients with temporal lobe epilepsy

Highlights • The concentration of 5HT was evaluated in a large series of hippocampal tissue of homogeneous sample of patients. • All patients included had refractory temporal lobe epilepsy caused by hippocampal sclerosis. • Lower concentrations of 5HT were correlated with a history of GTC seizures....

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Bibliographic Details
Published in:Epilepsy research 2015-03, Vol.111, p.18-25
Main Authors: da Fonseca, Natascha C, Joaquim, Helena P.G, Talib, Leda L, de Vincentiis, Silvia, Gattaz, Wagner F, Valente, Kette D
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Child
Chromatography, High Pressure Liquid
Depression - complications
Depression - metabolism
Epilepsy, Temporal Lobe - complications
Epilepsy, Temporal Lobe - metabolism
Epilepsy, Temporal Lobe - surgery
Female
Hippocampus - metabolism
Hippocampus - surgery
Humans
Male
Middle Aged
Neurology
Psychotic Disorders - complications
Psychotic Disorders - metabolism
Seizures - complications
Seizures - metabolism
Seizures - surgery
Serotonin - deficiency
Young Adult
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Summary:Highlights • The concentration of 5HT was evaluated in a large series of hippocampal tissue of homogeneous sample of patients. • All patients included had refractory temporal lobe epilepsy caused by hippocampal sclerosis. • Lower concentrations of 5HT were correlated with a history of GTC seizures. • The presence of psychiatric disorders was not correlated with 5 HT levels.
ISSN:0920-1211
1872-6844
DOI:10.1016/j.eplepsyres.2014.12.013