Stability and selectivity of a chronic, multi-contact cuff electrode for sensory stimulation in human amputees

Objective. Stability and selectivity are important when restoring long-term, functional sensory feedback in individuals with limb-loss. Our objective is to demonstrate a chronic, clinical neural stimulation system for providing selective sensory response in two upper-limb amputees. Approach. Multi-c...

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Bibliographic Details
Published in:Journal of neural engineering 2015-04, Vol.12 (2), p.026002-026002
Main Authors: Tan, Daniel W, Schiefer, Matthew A, Keith, Michael W, Anderson, J Robert, Tyler, Dustin J
Format: Article
Language:English
Subjects:
Amputees - rehabilitation
Arm - innervation
Contact
Cuffs
Electric Stimulation Therapy - instrumentation
Electrodes
Electrodes, Implanted
Equipment Design
Equipment Failure Analysis
functional electrical stimulation (FES)
Humans
Male
Middle Aged
nerve electrodes
Nerves
peripheral nerve
Peripheral Nerves - physiopathology
prosthetics
Reproducibility of Results
selective stimulation
Selectivity
Sensation
Sensitivity and Specificity
Sensory feedback
Stability
Stimulation
upper extremity neuroprostheses
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Summary:Objective. Stability and selectivity are important when restoring long-term, functional sensory feedback in individuals with limb-loss. Our objective is to demonstrate a chronic, clinical neural stimulation system for providing selective sensory response in two upper-limb amputees. Approach. Multi-contact cuff electrodes were implanted in the median, ulnar, and radial nerves of the upper-limb. Main results. Nerve stimulation produced a selective sensory response on 19 of 20 contacts and 16 of 16 contacts in subjects 1 and 2, respectively. Stimulation elicited multiple, distinct percept areas on the phantom and residual limb. Consistent threshold, impedance, and percept areas have demonstrated that the neural interface is stable for the duration of this on-going, chronic study. Significance. We have achieved selective nerve response from multi-contact cuff electrodes by demonstrating characteristic percept areas and thresholds for each contact. Selective sensory response remains consistent in two upper-limb amputees for 1 and 2 years, the longest multi-contact sensory feedback system to date. Our approach demonstrates selectivity and stability can be achieved through an extraneural interface, which can provide sensory feedback to amputees.
ISSN:1741-2560
1741-2552
DOI:10.1088/1741-2560/12/2/026002