Should all branch-duct intraductal papillary mucinous neoplasms be resected?

Abstract Background The relationship between branch-duct intraductal papillary mucinous neoplasms (IPMNs) and malignancy remains controversial and difficult to assess. Methods Between January 1, 1999 and January 1, 2013, we identified 84 patients with IPMN who underwent resection. Results Preoperati...

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Bibliographic Details
Published in:The American journal of surgery 2015-03, Vol.209 (3), p.478-482
Main Authors: Plichta, Jennifer K., M.D., M.S, Ban, Kristen, M.D, Fridirici, Zachary, M.D, Godambe, Anjali S., D.O, Yong, Sherri, M.D, Pappas, Sam, M.D, Abood, Gerard J., M.D., M.S, Aranha, Gerard V., M.D., F.R.C.S.C., F.A.C.S
Format: Article
Language:English
Subjects:
Adenocarcinoma, Mucinous - diagnosis
Adenocarcinoma, Mucinous - surgery
Aged
Aged, 80 and over
Biopsy
Carcinoma, Pancreatic Ductal - diagnosis
Carcinoma, Pancreatic Ductal - surgery
Carcinoma, Papillary - diagnosis
Carcinoma, Papillary - surgery
Cellular biology
Confidence intervals
Decision Making
Endoscopy
Endosonography
Female
Follow-Up Studies
Humans
Intraductal papillary mucinous neoplasm
IPMN
Male
Middle Aged
Multivariate analysis
Neoplasm Staging
Pancreas
Pancreatectomy - methods
Pancreatic Ducts - surgery
Pancreatic Neoplasms - diagnosis
Pancreatic Neoplasms - surgery
Pathology
Prognosis
Retrospective Studies
Surgery
Treatment Outcome
Tumors
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Summary:Abstract Background The relationship between branch-duct intraductal papillary mucinous neoplasms (IPMNs) and malignancy remains controversial and difficult to assess. Methods Between January 1, 1999 and January 1, 2013, we identified 84 patients with IPMN who underwent resection. Results Preoperatively, 55 patients underwent endoscopic ultrasounds and 58 underwent biopsy. Only 7 lesions were specified preoperatively as branch-duct, which inconsistently correlated with the surgical specimen. Of the 82 patients where the duct was specified, there were 33 malignant lesions. There was no correlation between branch-duct origin and invasive carcinoma. Malignant tumor size did not significantly differ by the duct of origin. Of the 28 patients with invasive carcinoma, branch-duct lesions were significantly associated with the presence of positive lymph nodes, perineural invasion, and lymphovascular invasion. Conclusions Our study supports the resection criteria for branch-duct IPMN based on size and symptoms. However, it also questions the reliability of our preoperative testing to rule out malignant branch-duct IPMN lesions.
ISSN:0002-9610
1879-1883
DOI:10.1016/j.amjsurg.2014.10.010