Canine distemper virus DNA vaccination of mink can overcome interference by maternal antibodies

Highlights • Canine distemper virus (CDV) DNA vaccination can overcome maternal antibodies. • DNA vaccination of 5 days old kits induces virus specific neutralising antibodies. • CDV DNA vaccination early in life induces long lived immunity. • DNA vaccination induced protection against virulent fiel...

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Bibliographic Details
Published in:Vaccine 2015-03, Vol.33 (11), p.1375-1381
Main Authors: Jensen, Trine Hammer, Nielsen, Line, Aasted, Bent, Pertoldi, Cino, Blixenkrone-Møller, Merete
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Antibodies, Neutralizing
Antibodies, Viral - immunology
Canine distemper virus
Deoxyribonucleic acid
Distemper - prevention & control
Distemper Virus, Canine - immunology
Distemper Virus, Canine - pathogenicity
DNA
DNA vaccination
Hemagglutinins, Viral
Immune response
Immune system
Immunity, Maternally-Acquired
Immunologic Memory
Interferon-gamma - immunology
Interleukin-4 - immunology
Lymphocytes
Maternal antibodies
Mink
Mink - virology
Morbillivirus
Neonatal
Neutralization Tests
Nucleoproteins - immunology
Plasmids
T-Lymphocytes - immunology
Vaccines
Vaccines, Attenuated - immunology
Vaccines, DNA - immunology
Viral Vaccines - immunology
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Summary:Highlights • Canine distemper virus (CDV) DNA vaccination can overcome maternal antibodies. • DNA vaccination of 5 days old kits induces virus specific neutralising antibodies. • CDV DNA vaccination early in life induces long lived immunity. • DNA vaccination induced protection against virulent field strains of CDV.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2015.01.029