Influence of the c.1517G>C genetic variant in the XRCC1 gene on pancreatic cancer susceptibility in a Chinese population

• Published in: Genetics and molecular research 2014-06, Vol.13 (2), p.4466-4472
• Main Authors: Zhao, Z M, Li, C G, Hu, M G, Gao, Y X, Liu, R
• Format: Article
• Language: English
• Subjects: Adult; Aged; Asian Continental Ancestry Group - genetics; Case-Control Studies; China; DNA-Binding Proteins - genetics; Female; Genetic Association Studies; Genetic Predisposition to Disease; Genetic Variation; Humans; Male; Middle Aged; Pancreatic Neoplasms - genetics; Polymorphism, Single Nucleotide; X-ray Repair Cross Complementing Protein 1
• ISSN: 1676-5680; 1676-5680
• DOI: 10.4238/2014.June.16.5

We investigated the influence of the c.1517G>C genetic variant in the X-ray repair complementing group 1 gene (XRCC1) on pancreatic cancer (PC) susceptibility in Chinese patients. A total of 390 PC patients and 392 controls were enrolled in this case-control study. The genotypes of c.1517G>C genetic variants were determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Our findings suggested that the allele and genotype frequencies in PC patients were significantly different from those in cancer-free controls. The CC genotype was associated with an increased risk of PC compared to the wild-type GG genotype (odds ratio=2.43, 95% confidence interval 1.43-4.13, X2=11.19, P=0.001). The C allele may contribute to the development of PC (C vs G, odds ratio=1.32, 95% confidence interval 1.06-1.64, X2=6.25, P=0.012). Results from this study indicate that the c.1517G>C genetic variant of the XRCC1 gene is significantly associated with PC susceptibility in the Chinese population.