Synthetic immunology: modulating the human immune system

Highlights • In synthetic immunology, biological devices are engineered to rationally modulate immune responses. • Molecules derived from the immune system are modified to capture cytokines or cells. • Autologous immune cells are designed to cure immunodeficiencies or eradicate tumors.

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Bibliographic Details
Published in:Trends in biotechnology (Regular ed.) 2015-02, Vol.33 (2), p.65-79
Main Authors: Geering, Barbara, Fussenegger, Martin
Format: Article
Language:English
Subjects:
adoptive immunotherapy
Allergy and Immunology - trends
Antibodies, Monoclonal - administration & dosage
Antibodies, Monoclonal - biosynthesis
antibody derivative
antibody mimetic
Autoimmune diseases
autologous hematopoietic stem cell transplantation
Biotechnology
Cell Engineering - methods
Cytotoxicity, Immunologic - drug effects
Dendritic Cells - cytology
Dendritic Cells - drug effects
Dendritic Cells - immunology
Genetic Therapy - methods
Humans
Immune response
Immune system
Immune System - drug effects
Immunology
Immunomodulation - drug effects
Immunotherapy, Adoptive - methods
Internal Medicine
Lymphocytes - cytology
Lymphocytes - drug effects
Lymphocytes - immunology
Lymphoma
Medical research
Monocytes - cytology
Monocytes - drug effects
Monocytes - immunology
protein engineering
Recombinant Proteins - administration & dosage
Recombinant Proteins - biosynthesis
synthetic biology
Synthetic Biology - methods
Synthetic Biology - trends
T cell receptors
Vaccines
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Description
Summary:Highlights • In synthetic immunology, biological devices are engineered to rationally modulate immune responses. • Molecules derived from the immune system are modified to capture cytokines or cells. • Autologous immune cells are designed to cure immunodeficiencies or eradicate tumors.
ISSN:0167-7799
1879-3096
DOI:10.1016/j.tibtech.2014.10.006