Spinal nerve involvement in early Guillain–Barré syndrome: A clinico-electrophysiological, ultrasonographic and pathological study

Highlights • We carried out clinical-electrophysiological evaluation, and ultrasonography of peripheral nerves and cervical nerves in 6 early Guillain–Barré patients, with detailed autopsy study in one of them. • Involvement of spinal nerves was an outstanding finding. • Inflammatory oedema of spina...

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Published in:Clinical neurophysiology 2015-04, Vol.126 (4), p.810-819
Main Authors: Gallardo, Elena, Sedano, María J, Orizaola, Pedro, Sánchez-Juan, Pascual, González-Suárez, Andrea, García, Antonio, Terán-Villagrá, Nuria, Ruiz-Soto, María, Álvaro, Rosa Landeras, Berciano, María T, Lafarga, Miguel, Berciano, José
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
AIDP
AMAN
AMSAN
Antiganglioside antibody
Axonal degeneration
Demyelination
Early Diagnosis
Electrophysiological Phenomena - physiology
Electrophysiology
Endoneurial oedema
Experimental allergic neuritis
Female
Guillain-Barre Syndrome - diagnostic imaging
Guillain-Barre Syndrome - physiopathology
Guillain–Barré syndrome
Humans
Male
Methylprednisolone
Middle Aged
Neurology
Spinal Nerves - diagnostic imaging
Spinal Nerves - physiopathology
Ultrasonography
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Summary:Highlights • We carried out clinical-electrophysiological evaluation, and ultrasonography of peripheral nerves and cervical nerves in 6 early Guillain–Barré patients, with detailed autopsy study in one of them. • Involvement of spinal nerves was an outstanding finding. • Inflammatory oedema of spinal nerves is a pathogenically relevant feature to understanding the mechanism of ascending paralysis.
ISSN:1388-2457
1872-8952
DOI:10.1016/j.clinph.2014.06.051