Cortical hyperexcitability precedes lower motor neuron dysfunction in ALS

Highlights • Cortical hyperexcitability appears to develop prior to onset of lower motor neuron dysfunction in amyotrophic lateral sclerosis (ALS). • Cortical hyperexcitability is intrinsic to ALS. • Cortical hyperexcitability may be the primary event in ALS, suggesting a cortical origin of the dise...

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Bibliographic Details
Published in:Clinical neurophysiology 2015-04, Vol.126 (4), p.803-809
Main Authors: Menon, Parvathi, Kiernan, Matthew C, Vucic, Steve
Format: Article
Language:English
Subjects:
Adult
Aged
Amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis - diagnosis
Amyotrophic Lateral Sclerosis - physiopathology
Cohort Studies
Cortical hyperexcitability
Dying forward
Electromyography - methods
Evoked Potentials, Motor - physiology
Female
Humans
Male
Middle Aged
Motor Cortex - physiopathology
Motor neuron
Motor Neurons - physiology
Muscle, Skeletal - physiopathology
Neurology
Prospective Studies
Transcranial Magnetic Stimulation - methods
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Summary:Highlights • Cortical hyperexcitability appears to develop prior to onset of lower motor neuron dysfunction in amyotrophic lateral sclerosis (ALS). • Cortical hyperexcitability is intrinsic to ALS. • Cortical hyperexcitability may be the primary event in ALS, suggesting a cortical origin of the disease.
ISSN:1388-2457
1872-8952
DOI:10.1016/j.clinph.2014.04.023