Associations of MC3R polymorphisms with physical activity in South African adolescents

There is evidence demonstrating that the contribution of sedentary behavior and effect of physical activity on metabolic phenotypes is mediated by polymorphisms in genes. The type and frequency of physical activity was assessed by means of structured questionnaires in 1555 South African school learn...

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Bibliographic Details
Published in:Journal of physical activity & health 2013-08, Vol.10 (6), p.813-825
Main Authors: Yako, Yandiswa Y, Hassan, Mogamat S, Erasmus, Rajiv T, van der Merwe, Lize, Janse van Rensburg, Susan, Matsha, Tandi Edith
Format: Article
Language:English
Subjects:
Adolescent
Blood Pressure - genetics
Cholesterol - genetics
Cross-Sectional Studies
Exercise
Female
Genotype
Humans
Lipids - genetics
Male
Metabolism
Motor Activity
Obesity - genetics
Phenotype
Polymorphism, Genetic
Receptor, Melanocortin, Type 3 - genetics
Sedentary Lifestyle
South Africa
Surveys and Questionnaires
Teenagers
Waist Circumference
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Summary:There is evidence demonstrating that the contribution of sedentary behavior and effect of physical activity on metabolic phenotypes is mediated by polymorphisms in genes. The type and frequency of physical activity was assessed by means of structured questionnaires in 1555 South African school learners. Anthropometric measurements, blood pressure, fasting blood glucose and lipids were measured using standard procedures. The effect of different types and frequency of physical activity on obesity-related traits was assessed in relation to MC3R T6K and V81I genotypes in 430 of the learners. Levels of total cholesterol were significantly lower in learners carrying the MC3R T6K and V81I minor alleles, after adjusting for age, race, gender, and each specific physical activity category. An activity-by-genotype interaction was also detected: learners heterozygous for the V81I polymorphism and performed house chores often had reduced total cholesterol. Though no association was observed between frequency of physical activity and BMI, television viewing was significantly associated with an increase in height, weight and marginally with waist circumference. Our findings suggest that physical activity even in the form of house chores has a positive effect on metabolic traits and this effect is further enhanced in the presence of MC3R polymorphisms.
ISSN:1543-3080
1543-5474
DOI:10.1123/jpah.10.6.813