Spontaneous Nonneoplastic Lesions in Control Syrian Hamsters in Three 24-month Long-term Carcinogenicity Studies

Information about the incidence of spontaneously occurring, nonneoplastic background findings in Syrian hamsters is essential if Syrian hamsters are to be used for toxicity studies. Male and female Syrian hamsters of the strain Han:AURA from the Fraunhofer Institute for Toxicology and Experimental M...

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Bibliographic Details
Published in:Toxicologic pathology 2015-02, Vol.43 (2), p.272-281
Main Authors: McInnes, Elizabeth F., Ernst, Heinrich, Germann, Paul-Georg
Format: Article
Language:English
Subjects:
Animal Diseases - epidemiology
Animal Diseases - mortality
Animal Diseases - pathology
Animals
Carcinogenicity Tests
Cricetinae
Female
Incidence
Male
Mesocricetus - physiology
Neoplasms - epidemiology
Neoplasms - pathology
Pathology - standards
Reference Standards
Toxicology - standards
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Summary:Information about the incidence of spontaneously occurring, nonneoplastic background findings in Syrian hamsters is essential if Syrian hamsters are to be used for toxicity studies. Male and female Syrian hamsters of the strain Han:AURA from the Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM) breeding colony were maintained as control animals for carcinogenicity studies and were examined for the presence of nonneoplastic background findings either when they died or when the study was terminated. The nonneoplastic background lesions observed at an incidence of >50% (high), >25% (moderate), and >10% (low) in either male or female animals or in both sexes in one or more long-term studies are detailed. The results are compared to previous published reports of nonneoplastic, spontaneous background lesions in Syrian hamsters. Background information about the incidence of background lesions in Syrian hamsters on short- and long-term studies is useful to both toxicologists and toxicological pathologists.
ISSN:0192-6233
1533-1601
DOI:10.1177/0192623314532569