What are residual symptoms in schizophrenia spectrum disorder? Clinical description and 1-year persistence within a naturalistic trial

The aim of this study was to evaluate residual symptoms in patients achieving remission according to the consensus criteria and to analyze their potential influence on the patient’s outcome one year after discharge. In total, 399 patients suffering from a schizophrenia spectrum disorder were evaluat...

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Published in:European archives of psychiatry and clinical neuroscience 2015-03, Vol.265 (2), p.107-116
Main Authors: Schennach, Rebecca, Riedel, Michael, Obermeier, Michael, Spellmann, Ilja, Musil, Richard, Jäger, Markus, Schmauss, Max, Laux, Gerd, Pfeiffer, Herbert, Naber, Dieter, Schmidt, Lutz G., Gaebel, Wolfgang, Klosterkötter, Joachim, Heuser, Isabella, Maier, Wolfgang, Lemke, Matthias R., Rüther, Eckart, Klingberg, Stefan, Gastpar, Markus, Möller, Hans-Jürgen
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Antipsychotic Agents - therapeutic use
Diagnostic and Statistical Manual of Mental Disorders
Female
Follow-Up Studies
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Neurosciences
Original Paper
Psychiatric Status Rating Scales
Psychiatry
Psychopathology
Psychotic Disorders - complications
Psychotic Disorders - diagnosis
Psychotic Disorders - drug therapy
Recurrence
Retrospective Studies
Schizophrenia - complications
Schizophrenia - diagnosis
Schizophrenia - drug therapy
Schizophrenic Psychology
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Summary:The aim of this study was to evaluate residual symptoms in patients achieving remission according to the consensus criteria and to analyze their potential influence on the patient’s outcome one year after discharge. In total, 399 patients suffering from a schizophrenia spectrum disorder were evaluated within a naturalistic study. Remission status was examined using the consensus criteria. Residual symptoms were defined as any symptom present at the time-point of remission following analogous analyses performed in depressed patients. Therefore, a PANSS item with a symptom severity of >1 (= at least borderline mentally ill) was defined to be a residual symptom. Remitters with and without residual symptoms were compared regarding psychopathology, functioning and side effects. In total, 236 patients (59 %) were remitters at discharge with 94 % of them suffering from at least one residual symptom. The most common residual symptoms were blunted affect (49 %), conceptual disorganization (42 %) and social withdrawal (40 %). A significant association was found between the presence of residual symptoms and the severity of side effects ( p  
ISSN:0940-1334
1433-8491
DOI:10.1007/s00406-014-0528-2