Biotransformation of alkenes by haloperoxidases : regiospecific bromohydrin formation from cinnamyl substrates

A study of bromohydrin formation from some cinnamyl substrates by the heme-dependent chloroperoxidase from Caldariomyces fumago has identified differences in the regio- and diastereospecificity of this enzyme relative to chemical hydrobromination. Diastereospecificity of bromohydrin formation from (...

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Bibliographic Details
Published in:Biotechnology letters 1993-09, Vol.15 (9), p.907-912
Main Authors: COUGHLIN, P, ROBERTS, S, RUSH, C, WILLETTS, A
Format: Article
Language:English
Subjects:
Bioconversions. Hemisynthesis
Biological and medical sciences
Biotechnology
Caldariomyces fumago
Corallina officinalis
Fundamental and applied biological sciences. Psychology
Methods. Procedures. Technologies
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Summary:A study of bromohydrin formation from some cinnamyl substrates by the heme-dependent chloroperoxidase from Caldariomyces fumago has identified differences in the regio- and diastereospecificity of this enzyme relative to chemical hydrobromination. Diastereospecificity of bromohydrin formation from (E)-4-phenyl-buten-2-ol by the vanadium-dependent bromoperoxidase from the alga Corallina officinalis is similar to that of the fungal enzyme but significantly different to the equivalent chemical reaction. (DBO)
ISSN:0141-5492
1573-6776
DOI:10.1007/BF00131755