Comparison of Lesion Improvement in Lupoid Leishmaniasis Patients with Two Treatment Approaches: Trichloroacetic Acid and Intralesional Meglumine Antimoniate

• Published in: Journal of cutaneous medicine and surgery 2015-01, Vol.19 (1), p.35-39
• Main Authors: Banihashemi, Mahnaz, Yazdanpanah, Mohamad Javad, Amirsolymani, Hossein, Yousefzadeh, Hadis
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Antiprotozoal Agents - administration & dosage; Antiprotozoal Agents - adverse effects; Child; Child, Preschool; Humans; Injections, Intralesional; Leishmaniasis, Cutaneous - drug therapy; Leishmaniasis, Cutaneous - pathology; Male; Meglumine - administration & dosage; Meglumine - adverse effects; Organometallic Compounds - administration & dosage; Organometallic Compounds - adverse effects; Skin - pathology; Treatment Outcome; Trichloroacetic Acid - administration & dosage; Trichloroacetic Acid - adverse effects; Young Adult
• ISSN: 1203-4754; 1615-7109
• DOI: 10.2310/7750.2014.13193

Background: There are several therapies for treating lupoid leishmaniasis. We compared the effectiveness of intralesional meglumine antimoniate (MA) and topical application of trichloroacetic acid (TCA) 50% solution. Methods: This study was a randomized clinical trial comprising 60 lupoid leishmaniasis patients. The first group received intralesional MA once a week, and the second group was treated once weekly with TCA 50% topical solution. The results were recorded once after 8 weeks and then 3 months after the termination of treatment. Results: The total clearance rates after treatment and after the 3-month follow-up were, respectively, 48.1% and 40% in the first group and 44.4% and 36.6% in the second group. There was no significant difference between the two treatment groups (p = .25 and p = .26). In both groups, the most common side effect was scarring. Conclusion: Having almost the same efficacies, TCA as a topical approach could be as effective as MA in the lupoid leishmaniasis treatment plan.