Diastereoselective Aminooxygenation and Diamination of Alkenes with Amidines by Hypervalent Iodine(III) Reagents

Diastereoselective anti-aminooxygenation and anti-diamination of alkenes with amidines were enabled by hypervalent iodine(III) reagents such as PhI(OCOR)2 and PhI(NMs2)2, respectively. The present transformation offers diastereochemically pure dihydroimidazoles divergently from E- and Z-alkenes.

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Bibliographic Details
Published in:Organic letters 2014-12, Vol.16 (23), p.6136-6139
Main Authors: Chen, Hui, Kaga, Atsushi, Chiba, Shunsuke
Format: Article
Language:English
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Summary:Diastereoselective anti-aminooxygenation and anti-diamination of alkenes with amidines were enabled by hypervalent iodine(III) reagents such as PhI(OCOR)2 and PhI(NMs2)2, respectively. The present transformation offers diastereochemically pure dihydroimidazoles divergently from E- and Z-alkenes.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol503000c