Highly Stereoselective Ruthenium(II)-Catalyzed Direct C2-syn-Alkenylation of Indoles with Alkynes

A carboamide-directed ruthenium-catalyzed C2-hydroindolation of alkynes has been described. This transformation provides a rapid access to free (N–H) C2-syn-alkenylated indole derivatives with the assistance of copper(II) salts, in which the directing group is removed via a one-pot process.

Saved in:
Bibliographic Details
Published in:Organic letters 2015-03, Vol.17 (6), p.1349-1352
Main Authors: Zhang, Wei, Wei, Jun, Fu, Shaomin, Lin, Dongen, Jiang, Huanfeng, Zeng, Wei
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A carboamide-directed ruthenium-catalyzed C2-hydroindolation of alkynes has been described. This transformation provides a rapid access to free (N–H) C2-syn-alkenylated indole derivatives with the assistance of copper(II) salts, in which the directing group is removed via a one-pot process.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol503618m