Erythroid progenitors from patients with low-risk myelodysplastic syndromes are dependent on the surrounding micro environment for their survival

To investigate whether the type of programmed cell death of myelodysplastic erythroid cells depends on their cellular context, we performed studies on cells from patients with low-risk myelodysplastic syndromes. We compared erythroid cells (and their precursor cells) from the mononuclear cell fracti...

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Bibliographic Details
Published in:Experimental hematology 2015-03, Vol.43 (3), p.215-222.e2
Main Authors: Folkerts, Hendrik, Hazenberg, Carin L.E, Houwerzijl, Ewout J, van den Heuvel, Fiona A.J, Mulder, André B, van der Want, Johannes J.L, Vellenga, Edo
Format: Article
Language:English
Subjects:
Advanced Basic Science
Aged
Aged, 80 and over
Apoptosis
Cell Survival
Cells, Cultured
Erythroid Precursor Cells - pathology
Erythroid Precursor Cells - physiology
Female
Flow Cytometry
Hematology, Oncology and Palliative Medicine
Humans
Leukocytes, Mononuclear - pathology
Male
Middle Aged
Myelodysplastic Syndromes - physiopathology
Real-Time Polymerase Chain Reaction
Risk Factors
Tumor Microenvironment
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Summary:To investigate whether the type of programmed cell death of myelodysplastic erythroid cells depends on their cellular context, we performed studies on cells from patients with low-risk myelodysplastic syndromes. We compared erythroid cells (and their precursor cells) from the mononuclear cell fraction with those from the hematon fraction, which are compacted complexes of hematopoietic cells surrounded by their own micro-environment. In directly fixed materials, erythroblasts exhibited signs of autophagy with limited apoptosis (
ISSN:0301-472X
1873-2399
DOI:10.1016/j.exphem.2014.11.005