Pulmonary surfactant in the airway physiology: A direct relaxing effect on the smooth muscle

Highlights • Airway surfactant has an important role in the respiratory physiology. • Surfactant directly relaxes airway smooth muscle. • Surfactant dysfunction may be included in the pathophysiology of asthma, COPD or other diseases with bronchial obstruction.

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Bibliographic Details
Published in:Respiratory physiology & neurobiology 2015-04, Vol.209, p.95-105
Main Authors: Calkovska, A, Uhliarova, B, Joskova, M, Franova, S, Kolomaznik, M, Calkovsky, V, Smolarova, S
Format: Article
Language:English
Subjects:
Animals
Biological Products - pharmacology
Cystic Fibrosis Transmembrane Conductance Regulator - antagonists & inhibitors
Cystic Fibrosis Transmembrane Conductance Regulator - metabolism
Dose-Response Relationship, Drug
Enzyme Inhibitors - pharmacology
Glyburide - pharmacology
Glycine - analogs & derivatives
Glycine - pharmacology
Guinea Pigs
Humans
Hydrazines - pharmacology
KATP Channels - antagonists & inhibitors
KATP Channels - metabolism
Lung - drug effects
Lung - physiology
Medical Education
Muscle Relaxation - drug effects
Muscle Relaxation - physiology
Muscle, Smooth - drug effects
Muscle, Smooth - physiology
NG-Nitroarginine Methyl Ester - pharmacology
Nitric Oxide Synthase - antagonists & inhibitors
Nitric Oxide Synthase - metabolism
Obstruction
Phospholipids - pharmacology
Pulmonary surfactant
Pulmonary Surfactants - pharmacology
Pulmonary/Respiratory
Relaxation
Smooth muscle
Tissue Culture Techniques
Trachea - drug effects
Trachea - physiology
Upper and lower airways
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Description
Summary:Highlights • Airway surfactant has an important role in the respiratory physiology. • Surfactant directly relaxes airway smooth muscle. • Surfactant dysfunction may be included in the pathophysiology of asthma, COPD or other diseases with bronchial obstruction.
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2015.01.004