Removal of Plutonium and Americium from the Rat Using 3,4,3-LIHOPO and DTPA after Simulated Wound Contamination: Effect of Delayed Administration and Mass of Plutonium

• Published in: Radiation protection dosimetry 1994-01, Vol.53 (1-4), p.319-322
• Main Authors: Gray, S.A., Stradling, G.N., Pearce, M.J., Wilson, I., Moody, J.C., Burgada, R., Durbin, P.W., Raymond, K.N.
• Format: Article
• Language: English
• Subjects: Applied radiobiology (equipment, dosimetry...); Biological and medical sciences; Biological effects of radiation; Fundamental and applied biological sciences. Psychology; Tissues, organs and organisms biophysics
• ISSN: 0144-8420; 1742-3406
• DOI: 10.1093/oxfordjournals.rpd.a082301

The comparative efficacies of treatment with 3,4,3-LIHOPO and DTPA have been investigated in the rat after their subcutaneous and intramuscular injection. Commencement of treatment was delayed 30 min, 6 h or 1 d and the animals killed at 7 d. Under all conditions, 3,4,3-LIHOPO was considerably more effective than DTPA, although the efficacy of both ligands and their relative effectiveness decreased rapidly with their delay in administration. After early treatment of the intramuscular deposit of Pu and Am with 3,4,3-LIHOPO, the body content of Pu and Am was about 1% of those in untreated animals and about 30 times less than when using the same treatment regimen with DTPA. The value for Pu increased to 5% of controls when the amount deposited increased from 1.5 ng to 0.9 mg.kg -1 body mass.