Immediate Early Gene Expression Associated with the Persistence of Heterosynaptic Long-Term Depression in the Hippocampus

Long-term depression (LTD) of synaptic efficacy is likely to be as important in memory processing as the more well-known long-term potentiation (LTP). The case for LTD serving as a memory mechanism, however, requires that it be shown to persist across days or weeks at least. Here we examined the per...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1994-10, Vol.91 (21), p.10049-10053
Main Authors: Abraham, Wickliffe C., Christie, Brian R., Logan, Barbara, Lawlor, Patricia, Dragunow, Michael
Format: Article
Language:English
Subjects:
Animals
Dentate gyrus
Electric Stimulation
Gene Expression
Genes, Immediate-Early
Genetics
Hippocampus
Hippocampus - physiology
Immediate early genes
Long term depression
Long term potentiation
Long-Term Potentiation - physiology
Male
Memory
Memory - physiology
Mental depression
Neurology
Neuronal Plasticity - physiology
Neuroscience
Perforant pathway
Rats
Rats, Sprague-Dawley
Regression Analysis
Rodents
Synapses
Synapses - physiology
Synaptic Transmission
Time constants
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Summary:Long-term depression (LTD) of synaptic efficacy is likely to be as important in memory processing as the more well-known long-term potentiation (LTP). The case for LTD serving as a memory mechanism, however, requires that it be shown to persist across days or weeks at least. Here we examined the persistence of heterosynaptic LTD in the medial and lateral perforant path inputs to the dentate gyrus in awake rats and correlated this persistence with the degree of immediate early gene expression as assessed immunohistochemically. Rats were chronically implanted with separate stimulating electrodes in the medial and lateral perforant paths and an extracellular field potential recording electrode in the dentate hilus. After recovery from surgery, either the medial or the lateral perforant path was tetanized with 400-Hz trains, and homosynaptic LTP and heterosynaptic LTD were followed across time. Heterosynaptic LTD was shown to occur readily in awake animals and to persist across days or weeks, depending on the stimulation protocol. The persistence of LTD and LTP was highly correlated within animals. Additional animals, given the same tetanization protocols, showed that the greatest immediate early gene expression occurred following that protocol which consistently gave the longest-lasting LTP and LTD. These data support the proposed role of LTD in memory processing but question whether immediate early genes are important for the persistence of LTP, LTD, or both.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.91.21.10049