Integrated Ugi-Based Assembly of Functionally, Skeletally, and Stereochemically Diverse 1,4-Benzodiazepin-2-ones

A practical, integrated and versatile U-4CR-based assembly of 1,4-benzodiazepin-2-ones exhibiting functionally, skeletally, and stereochemically diverse substitution patterns is described. By virtue of its convergence, atom economy, and bond-forming efficiency, the methodology documented herein exem...

Full description

Saved in:
Bibliographic Details
Published in:Journal of organic chemistry 2015-02, Vol.80 (3), p.1533-1549
Main Authors: Azuaje, Jhonny, Pérez-Rubio, José M, Yaziji, Vicente, El Maatougui, Abdelaziz, González-Gomez, José Carlos, Sánchez-Pedregal, Vı́ctor M, Navarro-Vázquez, Armando, Masaguer, Christian F, Teijeira, Marta, Sotelo, Eddy
Format: Article
Language:English
Subjects:
Benzodiazepinones - chemistry
Combinatorial Chemistry Techniques
Molecular Structure
Organic Chemistry Phenomena
Stereoisomerism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A practical, integrated and versatile U-4CR-based assembly of 1,4-benzodiazepin-2-ones exhibiting functionally, skeletally, and stereochemically diverse substitution patterns is described. By virtue of its convergence, atom economy, and bond-forming efficiency, the methodology documented herein exemplifies the reconciliation of structural complexity and experimental simplicity in the context of medicinal chemistry projects.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo502382q