Integrated Ugi-Based Assembly of Functionally, Skeletally, and Stereochemically Diverse 1,4-Benzodiazepin-2-ones

A practical, integrated and versatile U-4CR-based assembly of 1,4-benzodiazepin-2-ones exhibiting functionally, skeletally, and stereochemically diverse substitution patterns is described. By virtue of its convergence, atom economy, and bond-forming efficiency, the methodology documented herein exem...

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Published in:Journal of organic chemistry 2015-02, Vol.80 (3), p.1533-1549
Main Authors: Azuaje, Jhonny, Pérez-Rubio, José M, Yaziji, Vicente, El Maatougui, Abdelaziz, González-Gomez, José Carlos, Sánchez-Pedregal, Vı́ctor M, Navarro-Vázquez, Armando, Masaguer, Christian F, Teijeira, Marta, Sotelo, Eddy
Format: Article
Language:English
Subjects:
Benzodiazepinones - chemistry
Combinatorial Chemistry Techniques
Molecular Structure
Organic Chemistry Phenomena
Stereoisomerism
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cited_by cdi_FETCH-LOGICAL-a416t-1a8f485552599c013d85ca85a23168d11c1170e0c16e410138843a7022020be53
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container_end_page 1549
container_issue 3
container_start_page 1533
container_title Journal of organic chemistry
container_volume 80
creator Azuaje, Jhonny
Pérez-Rubio, José M
Yaziji, Vicente
El Maatougui, Abdelaziz
González-Gomez, José Carlos
Sánchez-Pedregal, Vı́ctor M
Navarro-Vázquez, Armando
Masaguer, Christian F
Teijeira, Marta
Sotelo, Eddy
description A practical, integrated and versatile U-4CR-based assembly of 1,4-benzodiazepin-2-ones exhibiting functionally, skeletally, and stereochemically diverse substitution patterns is described. By virtue of its convergence, atom economy, and bond-forming efficiency, the methodology documented herein exemplifies the reconciliation of structural complexity and experimental simplicity in the context of medicinal chemistry projects.
doi_str_mv 10.1021/jo502382q
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source American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list)
subjects Benzodiazepinones - chemistry
Combinatorial Chemistry Techniques
Molecular Structure
Organic Chemistry Phenomena
Stereoisomerism
title Integrated Ugi-Based Assembly of Functionally, Skeletally, and Stereochemically Diverse 1,4-Benzodiazepin-2-ones
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