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Overexpression of survivin via activation of ERK1/2, Akt, and NF-κB plays a central role in vincristine resistance in multiple myeloma cells
Highlights • Vincristine resistance depends on overexpression of survivin. • Overexpression of survivin is involved in activation of ERK1/2, Akt, and NF-κB. • ERK1/2, Akt, and NF-κB inhibitors are potentially useful as anti-MDR agents.
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Published in: | Leukemia research 2015-04, Vol.39 (4), p.445-452 |
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Main Authors: | , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Highlights • Vincristine resistance depends on overexpression of survivin. • Overexpression of survivin is involved in activation of ERK1/2, Akt, and NF-κB. • ERK1/2, Akt, and NF-κB inhibitors are potentially useful as anti-MDR agents. |
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ISSN: | 0145-2126 1873-5835 |
DOI: | 10.1016/j.leukres.2015.01.016 |