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Overexpression of survivin via activation of ERK1/2, Akt, and NF-κB plays a central role in vincristine resistance in multiple myeloma cells

Highlights • Vincristine resistance depends on overexpression of survivin. • Overexpression of survivin is involved in activation of ERK1/2, Akt, and NF-κB. • ERK1/2, Akt, and NF-κB inhibitors are potentially useful as anti-MDR agents.

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Bibliographic Details
Published in:Leukemia research 2015-04, Vol.39 (4), p.445-452
Main Authors: Tsubaki, Masanobu, Takeda, Tomoya, Ogawa, Naoki, Sakamoto, Kotaro, Shimaoka, Hirotaka, Fujita, Arisa, Itoh, Tatsuki, Imano, Motohiro, Ishizaka, Toshihiko, Satou, Takao, Nishida, Shozo
Format: Article
Language:English
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Summary:Highlights • Vincristine resistance depends on overexpression of survivin. • Overexpression of survivin is involved in activation of ERK1/2, Akt, and NF-κB. • ERK1/2, Akt, and NF-κB inhibitors are potentially useful as anti-MDR agents.
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2015.01.016