Salmonella enterica : living a double life in epithelial cells

Highlights • Salmonella enterica resides within the cytosol or a membrane-bound vacuole in epithelial cells. • Intestinal and gall bladder epithelial cells are sites of cytosolic colonization in vivo. • Cytosolic Salmonella are transcriptionally distinct from vacuolar bacteria. • Epithelial cells co...

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Bibliographic Details
Published in:Current opinion in microbiology 2015-02, Vol.23, p.23-31
Main Author: Knodler, Leigh A
Format: Article
Language:English
Subjects:
Cell Death
Cytosol - microbiology
Epithelial Cells - microbiology
Epithelial Cells - physiology
Pathology
Salmonella typhimurium - growth & development
Salmonella typhimurium - metabolism
Salmonella typhimurium - physiology
Vacuoles - microbiology
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Summary:Highlights • Salmonella enterica resides within the cytosol or a membrane-bound vacuole in epithelial cells. • Intestinal and gall bladder epithelial cells are sites of cytosolic colonization in vivo. • Cytosolic Salmonella are transcriptionally distinct from vacuolar bacteria. • Epithelial cells containing cytosolic Salmonella are expelled by pyroptosis.
ISSN:1369-5274
1879-0364
DOI:10.1016/j.mib.2014.10.010