HTLV-1-associated infective dermatitis demonstrates low frequency of FOXP3-positive T-regulatory lymphocytes

Highlights • The pathogenesis of HTLV-1-associated infective dermatitis (ID)() is unclear. • Patients with ID may subsequently present with ATLL and/or HAM/TSP. • ID histopathology overlaps with lymphoid reactive and neoplastic proliferations. • ID demonstrates low frequency of Tregs as opposed to o...

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Bibliographic Details
Published in:Journal of dermatological science 2015-03, Vol.77 (3), p.150-155
Main Authors: Torres-Cabala, Carlos A, Curry, Jonathan L, Li Ning Tapia, Elsa ML, Ramos, Cesar, Tetzlaff, Michael T, Prieto, Victor G, Miranda, Roberto N, Bravo, Francisco
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
CD3 Complex - analysis
CD4-CD8 Ratio
Child
Child, Preschool
Chronic Disease
Dermatology
Eczema - immunology
Eczema - pathology
Eczema - virology
Female
Forkhead Transcription Factors - analysis
FoxP3
Histopathology
HTLV-1
HTLV-I Infections - immunology
HTLV-I Infections - pathology
Human T-lymphotropic virus 1
Humans
Immunohistochemistry
Infective dermatitis
Male
Middle Aged
Skin Diseases, Viral - immunology
Skin Diseases, Viral - pathology
T-Lymphocytes, Regulatory - chemistry
Tregs
Young Adult
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Description
Summary:Highlights • The pathogenesis of HTLV-1-associated infective dermatitis (ID)() is unclear. • Patients with ID may subsequently present with ATLL and/or HAM/TSP. • ID histopathology overlaps with lymphoid reactive and neoplastic proliferations. • ID demonstrates low frequency of Tregs as opposed to other inflammatory conditions. • Decreased numbers of Tregs may have a role in the pathogenesis of this disease.
ISSN:0923-1811
1873-569X
DOI:10.1016/j.jdermsci.2015.01.003