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Relationship Between Serum DNA Replication, Clinicopathological Characteristics and Prognosis of Hepatitis B Virus-associated Glomerulonephritis with Severe Proteinuria by Lamivudine Plus Adefovir Dipivoxil Combination Therapy
Objective To explore the relationship between HBV DNA and the clinical manifestations, pathological types, injury severity, and prognosis with HBV-GN. Methods 102 patients with HBV-GN were divided into 3 groups, according to the serum titer of the HBV DNA. 24-h urine protein excretion, and other par...
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| Published in: | Biomedical and environmental sciences 2015-03, Vol.28 (3), p.206-213 |
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| creator | JIANG, Wei LIU, Tuo DONG, Hui XU, Yan LIU, Li Qiu GUAN, Guang Ju LIU, Xiang Chun |
| description | Objective To explore the relationship between HBV DNA and the clinical manifestations, pathological types, injury severity, and prognosis with HBV-GN. Methods 102 patients with HBV-GN were divided into 3 groups, according to the serum titer of the HBV DNA. 24-h urine protein excretion, and other parameters were measured. Renal biopsy were performed. The association between HBV DNA and the pathological stage of membranous nephropathy was analyzed in 78 patients with HBV-MN. 24-h urine protein excretion was used for the evaluation of the prognosis, and the relationship between HBV DNA and prognosis were analyzed. Results Several findings were demonstrated with the increase of serum HBV DNA： 24-h urine protein excretion, plasma cholesterol, and triglycerides increased significantly（P〈0.05）, while the plasma level of albumin decreased significantly（P〈0.05）; The changes of serum creatinine, C3 and C4 were found but no statistical significance. Glomerular deposition of HBVAg increased, and the pathological injury was more severe. The clinical remission rate was lower in the high replication group after treatment as compared with the low replication group（P〈0.01）. Conclusion With the increase of serum HBV DNA, the urine protein excretion and the kidney injury were more severe, and the clinical remission rate was decreased. |
| doi_str_mv | 10.3967/bes2015.027 |
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Methods 102 patients with HBV-GN were divided into 3 groups, according to the serum titer of the HBV DNA. 24-h urine protein excretion, and other parameters were measured. Renal biopsy were performed. The association between HBV DNA and the pathological stage of membranous nephropathy was analyzed in 78 patients with HBV-MN. 24-h urine protein excretion was used for the evaluation of the prognosis, and the relationship between HBV DNA and prognosis were analyzed. Results Several findings were demonstrated with the increase of serum HBV DNA： 24-h urine protein excretion, plasma cholesterol, and triglycerides increased significantly（P〈0.05）, while the plasma level of albumin decreased significantly（P〈0.05）; The changes of serum creatinine, C3 and C4 were found but no statistical significance. Glomerular deposition of HBVAg increased, and the pathological injury was more severe. The clinical remission rate was lower in the high replication group after treatment as compared with the low replication group（P〈0.01）. Conclusion With the increase of serum HBV DNA, the urine protein excretion and the kidney injury were more severe, and the clinical remission rate was decreased.</description><identifier>ISSN: 0895-3988</identifier><identifier>EISSN: 2214-0190</identifier><identifier>DOI: 10.3967/bes2015.027</identifier><identifier>PMID: 25800445</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adefovir dipivoxil ; Adenine - analogs & derivatives ; Adenine - therapeutic use ; Adult ; Aged ; Antiviral Agents - therapeutic use ; DNA Replication ; DNA, Viral - blood ; DNA复制 ; Drug Therapy, Combination ; Female ; Glomerulonephritis - etiology ; Hepatitis B - complications ; Hepatitis B - drug therapy ; Hepatitis B virus ; Hepatitis B virus - genetics ; Humans ; Lamivudine ; Lamivudine - therapeutic use ; Male ; Middle Aged ; Nephritis ; Organophosphonates - therapeutic use ; Pathology ; Prognosis ; Proteinuria ; Proteinuria - etiology ; Young Adult ; 临床病理 ; 乙型肝炎病毒 ; 拉米夫定 ; 联合治疗 ; 血清 ; 阿德福韦酯 ; 预后</subject><ispartof>Biomedical and environmental sciences, 2015-03, Vol.28 (3), p.206-213</ispartof><rights>2015 The Editorial Board of Biomedical and Environmental Sciences</rights><rights>Copyright © 2015 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84046X/84046X.jpg</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0895398815300179$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27924,27925,45780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25800445$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>JIANG, Wei</creatorcontrib><creatorcontrib>LIU, Tuo</creatorcontrib><creatorcontrib>DONG, Hui</creatorcontrib><creatorcontrib>XU, Yan</creatorcontrib><creatorcontrib>LIU, Li Qiu</creatorcontrib><creatorcontrib>GUAN, Guang Ju</creatorcontrib><creatorcontrib>LIU, Xiang Chun</creatorcontrib><title>Relationship Between Serum DNA Replication, Clinicopathological Characteristics and Prognosis of Hepatitis B Virus-associated Glomerulonephritis with Severe Proteinuria by Lamivudine Plus Adefovir Dipivoxil Combination Therapy</title><title>Biomedical and environmental sciences</title><addtitle>Biomedical and Environmental Sciences</addtitle><description>Objective To explore the relationship between HBV DNA and the clinical manifestations, pathological types, injury severity, and prognosis with HBV-GN. Methods 102 patients with HBV-GN were divided into 3 groups, according to the serum titer of the HBV DNA. 24-h urine protein excretion, and other parameters were measured. Renal biopsy were performed. The association between HBV DNA and the pathological stage of membranous nephropathy was analyzed in 78 patients with HBV-MN. 24-h urine protein excretion was used for the evaluation of the prognosis, and the relationship between HBV DNA and prognosis were analyzed. Results Several findings were demonstrated with the increase of serum HBV DNA： 24-h urine protein excretion, plasma cholesterol, and triglycerides increased significantly（P〈0.05）, while the plasma level of albumin decreased significantly（P〈0.05）; The changes of serum creatinine, C3 and C4 were found but no statistical significance. Glomerular deposition of HBVAg increased, and the pathological injury was more severe. The clinical remission rate was lower in the high replication group after treatment as compared with the low replication group（P〈0.01）. Conclusion With the increase of serum HBV DNA, the urine protein excretion and the kidney injury were more severe, and the clinical remission rate was decreased.</description><subject>Adefovir dipivoxil</subject><subject>Adenine - analogs & derivatives</subject><subject>Adenine - therapeutic use</subject><subject>Adult</subject><subject>Aged</subject><subject>Antiviral Agents - therapeutic use</subject><subject>DNA Replication</subject><subject>DNA, Viral - blood</subject><subject>DNA复制</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Glomerulonephritis - etiology</subject><subject>Hepatitis B - complications</subject><subject>Hepatitis B - drug therapy</subject><subject>Hepatitis B virus</subject><subject>Hepatitis B virus - genetics</subject><subject>Humans</subject><subject>Lamivudine</subject><subject>Lamivudine - therapeutic use</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nephritis</subject><subject>Organophosphonates - therapeutic use</subject><subject>Pathology</subject><subject>Prognosis</subject><subject>Proteinuria</subject><subject>Proteinuria - etiology</subject><subject>Young Adult</subject><subject>临床病理</subject><subject>乙型肝炎病毒</subject><subject>拉米夫定</subject><subject>联合治疗</subject><subject>血清</subject><subject>阿德福韦酯</subject><subject>预后</subject><issn>0895-3988</issn><issn>2214-0190</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNo9kU1v1DAQhiMEokvhxB1ZnDiQ4jgf6xy3W9oirQCVwjVy7MlmkGOntpN2_y6_BO8HnEYzfub1q3mT5G1GL_K6Wn5qwTOalReULZ8lC8ayIqVZTZ8nC8rrMs1rzs-SV97_prTI6oK_TM5YyWNTlIvkzx1oEdAa3-NILiE8AhjyA9w0kKuvK3IHo0Z5ID6StUaD0o4i9FbbbZxrsu6FEzKAQx9QeiKMIt-d3Rrr0RPbkVuIPIbYXJJf6CafCu-tRBFAkRtth_iXtgbG3h2oRwx9NDCDg71QADSTQ0HaHdmIAedJoYkvevJkpaCzMzpyhSPO9gmjHTu0aA5-yX0PToy718mLTmgPb071PPl5_fl-fZtuvt18Wa82qWS8CGlWd8tS1K0oVFnXkMmuA8U5l4zykgvoWmAQD804QFewljJJeVUvRVkJkVcqP08-HHVHZx8m8KEZ0EvQWhiwk2-yqqqW-8vnEX13Qqd2ANWMDgfhds2_XCJQHgGIhmcE13iJYCQodCBDoyw2GW32-Ten_JuYf9x7f9yTvTXbBzTb_9pVVbC84qzI_wKy67Ph</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>JIANG, Wei</creator><creator>LIU, Tuo</creator><creator>DONG, Hui</creator><creator>XU, Yan</creator><creator>LIU, Li Qiu</creator><creator>GUAN, Guang Ju</creator><creator>LIU, Xiang Chun</creator><general>Elsevier B.V</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20150301</creationdate><title>Relationship Between Serum DNA Replication, Clinicopathological Characteristics and Prognosis of Hepatitis B Virus-associated Glomerulonephritis with Severe Proteinuria by Lamivudine Plus Adefovir Dipivoxil Combination Therapy</title><author>JIANG, Wei ; LIU, Tuo ; DONG, Hui ; XU, Yan ; LIU, Li Qiu ; GUAN, Guang Ju ; LIU, Xiang Chun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c284t-19f75a9ba4d599e1cffed888c20858aefbe2e20128eef42b02c08697a56aa36d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adefovir dipivoxil</topic><topic>Adenine - analogs & derivatives</topic><topic>Adenine - therapeutic use</topic><topic>Adult</topic><topic>Aged</topic><topic>Antiviral Agents - therapeutic use</topic><topic>DNA Replication</topic><topic>DNA, Viral - blood</topic><topic>DNA复制</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Glomerulonephritis - etiology</topic><topic>Hepatitis B - complications</topic><topic>Hepatitis B - drug therapy</topic><topic>Hepatitis B virus</topic><topic>Hepatitis B virus - genetics</topic><topic>Humans</topic><topic>Lamivudine</topic><topic>Lamivudine - therapeutic use</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nephritis</topic><topic>Organophosphonates - therapeutic use</topic><topic>Pathology</topic><topic>Prognosis</topic><topic>Proteinuria</topic><topic>Proteinuria - etiology</topic><topic>Young Adult</topic><topic>临床病理</topic><topic>乙型肝炎病毒</topic><topic>拉米夫定</topic><topic>联合治疗</topic><topic>血清</topic><topic>阿德福韦酯</topic><topic>预后</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>JIANG, Wei</creatorcontrib><creatorcontrib>LIU, Tuo</creatorcontrib><creatorcontrib>DONG, Hui</creatorcontrib><creatorcontrib>XU, Yan</creatorcontrib><creatorcontrib>LIU, Li Qiu</creatorcontrib><creatorcontrib>GUAN, Guang Ju</creatorcontrib><creatorcontrib>LIU, Xiang Chun</creatorcontrib><collection>维普_期刊</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>维普中文期刊数据库</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Biomedical and environmental sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>JIANG, Wei</au><au>LIU, Tuo</au><au>DONG, Hui</au><au>XU, Yan</au><au>LIU, Li Qiu</au><au>GUAN, Guang Ju</au><au>LIU, Xiang Chun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship Between Serum DNA Replication, Clinicopathological Characteristics and Prognosis of Hepatitis B Virus-associated Glomerulonephritis with Severe Proteinuria by Lamivudine Plus Adefovir Dipivoxil Combination Therapy</atitle><jtitle>Biomedical and environmental sciences</jtitle><addtitle>Biomedical and Environmental Sciences</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>28</volume><issue>3</issue><spage>206</spage><epage>213</epage><pages>206-213</pages><issn>0895-3988</issn><eissn>2214-0190</eissn><abstract>Objective To explore the relationship between HBV DNA and the clinical manifestations, pathological types, injury severity, and prognosis with HBV-GN. Methods 102 patients with HBV-GN were divided into 3 groups, according to the serum titer of the HBV DNA. 24-h urine protein excretion, and other parameters were measured. Renal biopsy were performed. The association between HBV DNA and the pathological stage of membranous nephropathy was analyzed in 78 patients with HBV-MN. 24-h urine protein excretion was used for the evaluation of the prognosis, and the relationship between HBV DNA and prognosis were analyzed. Results Several findings were demonstrated with the increase of serum HBV DNA： 24-h urine protein excretion, plasma cholesterol, and triglycerides increased significantly（P〈0.05）, while the plasma level of albumin decreased significantly（P〈0.05）; The changes of serum creatinine, C3 and C4 were found but no statistical significance. Glomerular deposition of HBVAg increased, and the pathological injury was more severe. The clinical remission rate was lower in the high replication group after treatment as compared with the low replication group（P〈0.01）. Conclusion With the increase of serum HBV DNA, the urine protein excretion and the kidney injury were more severe, and the clinical remission rate was decreased.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>25800445</pmid><doi>10.3967/bes2015.027</doi><tpages>8</tpages></addata></record> |
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| subjects | Adefovir dipivoxil Adenine - analogs & derivatives Adenine - therapeutic use Adult Aged Antiviral Agents - therapeutic use DNA Replication DNA, Viral - blood DNA复制 Drug Therapy, Combination Female Glomerulonephritis - etiology Hepatitis B - complications Hepatitis B - drug therapy Hepatitis B virus Hepatitis B virus - genetics Humans Lamivudine Lamivudine - therapeutic use Male Middle Aged Nephritis Organophosphonates - therapeutic use Pathology Prognosis Proteinuria Proteinuria - etiology Young Adult 临床病理 乙型肝炎病毒 拉米夫定 联合治疗 血清 阿德福韦酯 预后 |
| title | Relationship Between Serum DNA Replication, Clinicopathological Characteristics and Prognosis of Hepatitis B Virus-associated Glomerulonephritis with Severe Proteinuria by Lamivudine Plus Adefovir Dipivoxil Combination Therapy |
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