Revisiting the role of B cells in skin immune surveillance

Highlights • Circulating B cells express skin-associated homing receptors. • B cells are present in small numbers in normal unperturbed skin. • B cells accumulate at sites of cutaneous inflammation in parallel with T cells. • B cells have functional significance in animal and human models of skin pa...

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Bibliographic Details
Published in:Trends in immunology 2015-02, Vol.36 (2), p.102-111
Main Authors: Egbuniwe, Isioma U, Karagiannis, Sophia N, Nestle, Frank O, Lacy, Katie E
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Antigens
B cell
B-Lymphocytes - immunology
B-Lymphocytes - metabolism
Cell Movement - immunology
Dermatitis - genetics
Dermatitis - immunology
Dermatitis - metabolism
Humans
Immune system
Immunologic Surveillance
Lymphocytes
Medical research
Skin - immunology
Skin - metabolism
skin immune system
Skin Neoplasms - genetics
Skin Neoplasms - immunology
Skin Neoplasms - metabolism
skin pathology
skin surveillance
skin-homing lymphocyte
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Summary:Highlights • Circulating B cells express skin-associated homing receptors. • B cells are present in small numbers in normal unperturbed skin. • B cells accumulate at sites of cutaneous inflammation in parallel with T cells. • B cells have functional significance in animal and human models of skin pathology.
ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2014.12.006