The Implications of Obesity for Cardiac Arrhythmia Mechanisms and Management

Abstract The ever-increasing prevalence of obesity poses a significant burden on the health care system with escalating socioeconomic consequences. At the individual level, obesity is well recognized to increase morbidity and mortality. Not only is obesity an established cardiovascular risk factor,...

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Bibliographic Details
Published in:Canadian journal of cardiology 2015-02, Vol.31 (2), p.203-210
Main Authors: Pathak, Rajeev K., MBBS, Mahajan, Rajiv, MD, PhD, Lau, Dennis H., MBBS, PhD, Sanders, Prashanthan, MBBS, PhD
Format: Article
Language:English
Subjects:
Arrhythmias, Cardiac - epidemiology
Arrhythmias, Cardiac - etiology
Arrhythmias, Cardiac - therapy
Cardiovascular
Disease Management
Global Health
Heart Conduction System - physiopathology
Humans
Morbidity - trends
Obesity - complications
Obesity - epidemiology
Obesity - therapy
Risk Factors
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Summary:Abstract The ever-increasing prevalence of obesity poses a significant burden on the health care system with escalating socioeconomic consequences. At the individual level, obesity is well recognized to increase morbidity and mortality. Not only is obesity an established cardiovascular risk factor, it also increases the risk of sudden cardiac death and atrial fibrillation. Studies have shown that increased adiposity itself and the accompanying metabolic consequences of weight gain contribute to an abnormal arrhythmogenic substrate. In this review, we focus on the diverse mechanisms underlying cardiac arrhythmias related to obesity. In particular, we highlight the pathogenic role of adipose depots leading to increased atrial fibrillation and the effect of weight reduction in decreasing atrial fibrillation burden in obese individuals.
ISSN:0828-282X
1916-7075
DOI:10.1016/j.cjca.2014.10.027