Comparison of carbetocin and oxytocin effectiveness for prevention of postpartum hemorrhage after caesarean delivery

• Published in: Ginekologia polska 2015-02, Vol.86 (2), p.107-112
• Main Authors: Brzozowska, Maria, Lisiecki, Dawid, Kowalska-Koprek, Urszula, Karowicz-Bilińska, Agata
• Format: Article
• Language: eng ; pol
• Subjects: Adult; Cesarean Section - adverse effects; Delayed-Action Preparations - administration & dosage; Dose-Response Relationship, Drug; Female; Humans; Injections, Intravenous; Oxytocin - administration & dosage; Oxytocin - analogs & derivatives; Perinatal Care - methods; Postpartum Hemorrhage - etiology; Postpartum Hemorrhage - prevention & control; Pregnancy; Uterine Inertia - prevention & control; Young Adult
• ISSN: 0017-0011; 2543-6767
• DOI: 10.17772/gp/1996

The aim of the study was to compare the effectiveness of carbetocin and oxytocin for prevention of postpartum hemorrhage (PPH) after caesarean section. We analyzed data from 279 patients who received 100 μg of carbetocin intravenously or 10 IU of oxytocin into the uterine muscle as a rudimentary treatment for prevention of PPH. Blood loss was statistically significantly higher (p=0.0136) in the entire study group as compared to the oxytocin group, and in cases when additional uterotonics were administered (p=0.0090). Also, we observed a statistically significantly correlation between the need for additional treatment and patient BMI. Patients with pre-pregnancy BMI of ≥25 more often required additional medicaments after administration of carbetocin as compared to oxytocin (p=0.0077). We noted a statistically significantly higher rate of using additional treatment (p