Treatment of carcinomatosis using cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in adolescents and young adults

Abstract Background Among colorectal carcinoma patients, approximately 150 patients/year are age 25 years old or younger according to Surveillance, Epidemiology, and End Results Program statistics. Because of lack of screening in their age group, they are at risk to have more advanced disease and ha...

Full description

Saved in:
Bibliographic Details
Published in:The American journal of surgery 2015-04, Vol.209 (4), p.610-615
Main Authors: Oyeniyi, James, Wu, Jumin, M.S, Liu, Diane, M.S, Yao, James C., M.D, Green, Holly, P.A, Albritton, Karen, M.D, Huh, Winston, M.D, Hayes-Jordan, Andrea, M.D
Format: Article
Language:English
Subjects:
Adolescent
Adolescent and young adult
Adult
Adults
Age
Cancer therapies
Carcinoma - therapy
Chemotherapy
Chemotherapy, Cancer, Regional Perfusion
Colon carcinoma
Colorectal cancer
Colorectal Neoplasms - therapy
Combined Modality Therapy
Confidence intervals
Cytoreduction Surgical Procedures
HIPEC
Histology
Humans
Hyperthermia, Induced
Liver
Medical prognosis
Metastasis
Mutation
Ovarian cancer
Patients
Peritoneal
Population
Retrospective Studies
Surgery
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Background Among colorectal carcinoma patients, approximately 150 patients/year are age 25 years old or younger according to Surveillance, Epidemiology, and End Results Program statistics. Because of lack of screening in their age group, they are at risk to have more advanced disease and have been largely unstudied. Objective To determine outcome of colon cancer adolescent and young adult patients. Methods Patients under the age of 26 were retrospectively reviewed from a single institution. Results The 5-year overall survival rate from the time of the first surgery was .45 (95% confidence interval .17 to .70). The median overall survival for the cohort was 2.98 years. Patients aged 15 to 21 years had a poorer overall survival than patients aged 22 to 25 years (82% survival vs 100% at 2 years and zero vs 56% at 5 years). Five patients underwent cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Three are alive at 82, 36, and 16 weeks after hyperthermic intraperitoneal chemotherapy. Conclusions Patients less than 21 years with nonsyndromic colorectal carcinoma may have a poorer outcome. Novel, more aggressive therapy may be necessary in these patients.
ISSN:0002-9610
1879-1883
DOI:10.1016/j.amjsurg.2014.11.004