The effect of APH treatment on surface bonding and osseointegration of Ti-6Al-7Nb implants: An in vitro and in vivo study

This study investigated the effects of anodization-cyclic precalcification-heat (APH) treatment on the bonding ability of Ca-P coating to the parent metal and osseointegration of Ti-6Al-7Nb implants. Eighteen Ti-6Al-7Nb discs, 9 untreated and 9 APH-treated, were cultured with osteoblast cells in vit...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2015-04, Vol.103 (3), p.641-648
Main Authors: Nguyen, Thuy-Duong Thi, Moon, So-Hee, Oh, Tae-Ju, Park, Il-Song, Lee, Min-Ho, Bae, Tae-Sung
Format: Article
Language:English
Subjects:
Alkaline Phosphatase - analysis
Animals
Biomedical materials
Ca-P coating
Cells, Cultured
Coated Materials, Biocompatible - pharmacology
delamination
Dental Alloys - pharmacology
Dental Implants
Hot Temperature
Male
Materials research
Materials science
Materials Testing
Osseointegration
Osteoblasts - drug effects
Oxidation-Reduction
Oxides - pharmacology
Postoperative Period
Rats
Rats, Sprague-Dawley
Surface Properties
Ti-6Al-7Nb alloy
Tibia - metabolism
Tibia - pathology
Tibia - surgery
TiO2 nanotubes
Titanium - pharmacology
Torque
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Summary:This study investigated the effects of anodization-cyclic precalcification-heat (APH) treatment on the bonding ability of Ca-P coating to the parent metal and osseointegration of Ti-6Al-7Nb implants. Eighteen Ti-6Al-7Nb discs, 9 untreated and 9 APH-treated, were cultured with osteoblast cells in vitro, and the cellular differentiation ability was assayed at 1, 2, and 3 weeks. For in vivo testing, 28 Ti-6Al-7Nb implants (14 implants of each group) were inserted to rat tibias, and after each 4 and 6 weeks of implantation, bone bonding, and osseointegration were evaluated through removal torque and histological analysis. Osteoblast-culturing showed twice as much of the alkaline phosphatase activity on the treated surface at 3 weeks than on the untreated surface (p 
ISSN:1552-4973
1552-4981
DOI:10.1002/jbm.b.33210