Human Immunodeficiency Virus Type 1 Replication in Peripheral Blood Mononuclear Cells in the Presence of Cocaine

Previous studies haveshown that cocaineconsumption alters the normal immune functions of animals. Several epidemiologicstudies have indicated an association between cocaine consumption and an increased risk for AIDS. In the present studies, unstimulated peripheral blood mononuclear cells(PBMC) isola...

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Bibliographic Details
Published in:The Journal of infectious diseases 1993-11, Vol.168 (5), p.1157-1164
Main Authors: Bagasra, Omar, Pomerantz, Roger J.
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - pharmacology
Antigens
Biological and medical sciences
Cell lines
Cells, Cultured
Cocaine
Cocaine - analogs & derivatives
Cocaine - pharmacology
Cultured cells
Drug addictions
Giant cells
HIV 1
HIV Infections - complications
HIV-1 - drug effects
HIV-1 - growth & development
human immunodeficiency virus 1
Humans
Infections
Leukocytes, Mononuclear - microbiology
Lymphocytes
Major Articles
Medical sciences
Monocytes - microbiology
Peripheral blood mononuclear cells
Substance-Related Disorders - complications
T lymphocytes
T-Lymphocytes - microbiology
Toxicology
Virus Replication - drug effects
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Summary:Previous studies haveshown that cocaineconsumption alters the normal immune functions of animals. Several epidemiologicstudies have indicated an association between cocaine consumption and an increased risk for AIDS. In the present studies, unstimulated peripheral blood mononuclear cells(PBMC) isolated from 8 healthy, human immunodeficiency virus(HIV) type 1-sero-negative volunteers were exposed to cocaine or one of its by-products, in vitro, at concentrations compatible with blood levelsfound during clinical abuse of cocaine.PBMC treated with cocaine had significantly increased levels of HIV-1 replication after infection in vitro compared with untreated PBMC. The major cocaine by-product, benzoylecgonine, did not appear to exert any significant potentiating effect on HIV-1 replication. Cocaine or its by-product did not significantly increase HIV-1 replication in persistently HIV-1-infected T lymphocyticor monocytoid cell lines. These data indicate that exposure of PBMC but not chronically HIV-1-infected cell lines to cocaine can result in increased HIV-1 replication.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/168.5.1157