Promoting and synergistic effects of chrysazin on 1,2-dimethylhydrazine-induced carcinogenesis in male ICR/CD-1 mice

The modifying effects of chrysazin on 1,2-dimethylhydrazine (DMH)-indueed colon and liver carcinogenesis were examined in mate ICR/CD-1 mice. Starting at 6 weeks of age, mice were divided into four groups, two of which were treated with s.c. injections of DMH (20 mg/kg body wt) once a week for 12 we...

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Bibliographic Details
Published in:Carcinogenesis (New York) 1994-06, Vol.15 (6), p.1175-1179
Main Authors: Sugie, Shigeyuki, Mori, Yoshio, Okumura, Ataru, Yoshimi, Naoki, Okamoto, Kiyohisa, Sato, Suzuyo, Tanaka, Takuji, Mori, Hideki
Format: Article
Language:English
Subjects:
1,2-Dimethylhydrazine
Animals
Anthraquinones - toxicity
Biological and medical sciences
Carcinogenesis, carcinogens and anticarcinogens
Carcinogens - toxicity
Chemical agents
Colonic Neoplasms - chemically induced
Dimethylhydrazines - toxicity
Drug Synergism
Liver Neoplasms, Experimental - chemically induced
Male
Medical sciences
Mice
Mice, Inbred ICR
Mutagens - toxicity
Ornithine Decarboxylase - analysis
Tumors
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Summary:The modifying effects of chrysazin on 1,2-dimethylhydrazine (DMH)-indueed colon and liver carcinogenesis were examined in mate ICR/CD-1 mice. Starting at 6 weeks of age, mice were divided into four groups, two of which were treated with s.c. injections of DMH (20 mg/kg body wt) once a week for 12 weeks. A week after the final injection of DMH, one group was kept on the basal diet throughout the study (group I), and the other group was fed the diet containing chrysazin (mixed in basal diet at 0.2% concentration) alone for 42 weeks (group II). The other two groups were injected with normal saline and given the diet containing 0.2% chrysazin for 42 weeks (group III), or the basal diet during the experiment (group TV). The incidence and multiplicity of colon tumors of group II were significantly greater than those of group I (P
ISSN:0143-3334
1460-2180
DOI:10.1093/carcin/15.6.1175