Serotonin 2C receptor contributes to gender differences in stress-induced hypophagia in aged mice

Highlights • Novelty stress suppressed food intake in aged male mice markedly compared with aged female. • 5-HT2C R+ and c-Fos+ cells in the PVN was increased in stressed-aged male mice. • 5-HT2C R antagonists suppressed stress-induced hypophagia in aged male mice. • ERα agonist-induced food intake...

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Published in:Psychoneuroendocrinology 2015-05, Vol.55, p.81-93
Main Authors: Yamada, Chihiro, Sadakane, Chiharu, Nahata, Miwa, Saegusa, Yayoi, Nakagawa, Koji, Okubo, Naoto, Ohnishi, Shunsuke, Hattori, Tomohisa, Takeda, Hiroshi
Format: Article
Language:English
Subjects:
5-HT2CR
Age Factors
Aged
Aminopyridines - pharmacology
Animals
Anorexia
Aromatase Inhibitors - pharmacology
Brain - drug effects
Brain - metabolism
Brain - physiology
Corticosterone - metabolism
Endocrinology & Metabolism
ERRalpha Estrogen-Related Receptor
Feeding Behavior - drug effects
Feeding Behavior - physiology
Feeding Behavior - psychology
Female
Food intake
Gender differences
Ghrelin - metabolism
Ghrelin - pharmacology
Indoles - pharmacology
Letrozole
Male
Mice
Nitriles - pharmacology
Novelty stress
Paraventricular Hypothalamic Nucleus - drug effects
Paraventricular Hypothalamic Nucleus - metabolism
Paraventricular Hypothalamic Nucleus - physiology
Phenols - pharmacology
Piperazines - pharmacology
Psychiatry
Pyrazines - pharmacology
Pyrazoles - pharmacology
Receptor, Serotonin, 5-HT2C - genetics
Receptor, Serotonin, 5-HT2C - metabolism
Receptor, Serotonin, 5-HT2C - physiology
Receptors, Estrogen - physiology
Reverse Transcriptase Polymerase Chain Reaction
Rikkunshito
RNA, Messenger - metabolism
Serotonin 5-HT2 Receptor Agonists - pharmacology
Serotonin 5-HT2 Receptor Antagonists - pharmacology
Sex Factors
Stress, Psychological
Triazoles - pharmacology
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Summary:Highlights • Novelty stress suppressed food intake in aged male mice markedly compared with aged female. • 5-HT2C R+ and c-Fos+ cells in the PVN was increased in stressed-aged male mice. • 5-HT2C R antagonists suppressed stress-induced hypophagia in aged male mice. • ERα agonist-induced food intake reduction was reversed by 5-HT2C R antagonist.
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2015.02.006