Interactive effects of oligofructose and obesity predisposition on gut hormones and microbiota in diet‐induced obese rats

Objective Oligofructose (OFS) is a prebiotic that reduces energy intake and fat mass via changes in gut satiety hormones and microbiota. The effects of OFS may vary depending on predisposition to obesity. The aim of this study was to examine the effect of OFS in diet‐induced obese (DIO) and diet‐res...

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Published in:Obesity (Silver Spring, Md.) Md.), 2015-04, Vol.23 (4), p.769-778
Main Authors: Cluny, Nina L., Eller, Lindsay K., Keenan, Catherine M., Reimer, Raylene A., Sharkey, Keith A.
Format: Article
Language:English
Subjects:
Adiposity - drug effects
Animals
Body Composition - drug effects
Body Weight - drug effects
Diet
Dietary Fats - administration & dosage
Eating - drug effects
Gastrointestinal Hormones - metabolism
Ghrelin
Glucagon-Like Peptide 1 - metabolism
Hormones
Male
Microbiota
Obesity
Obesity - drug therapy
Obesity - metabolism
Oligosaccharides - administration & dosage
Prebiotics
Rats
Rats, Sprague-Dawley
Rodents
Satiation
Weight control
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Summary:Objective Oligofructose (OFS) is a prebiotic that reduces energy intake and fat mass via changes in gut satiety hormones and microbiota. The effects of OFS may vary depending on predisposition to obesity. The aim of this study was to examine the effect of OFS in diet‐induced obese (DIO) and diet‐resistant (DR) rats. Methods Adult, male DIO, and DR rats were randomized to: high‐fat/high‐sucrose (HFS) diet or HFS diet + 10% OFS for 6 weeks. Body composition, food intake, gut microbiota, plasma gut hormones, and cannabinoid CB1 receptor expression in the nodose ganglia were measured. Results OFS reduced body weight, energy intake, and fat mass in both phenotypes (P 
ISSN:1930-7381
1930-739X
DOI:10.1002/oby.21017