Neurochemical Alterations Associated with Borderline Personality Disorder

In neuroimaging on borderline personality disorder, prior studies focused on the hippocampus and amygdala, as mentioned above. However, no study investigated whether there were neurochemical changes in the patients with borderline personality disorder. Therefore, in the present study, we aimed to in...

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Bibliographic Details
Published in:International journal of psychiatry in medicine 2015-01, Vol.48 (4), p.317-324
Main Authors: Atmaca, Murad, Karakoc, Tevfik, Mermi, Osman, Gurkan Gurok, M., Yildirim, Hanefi
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aspartic Acid - analogs & derivatives
Aspartic Acid - metabolism
Borderline Personality Disorder - physiopathology
Brain
Choline - metabolism
Comparative analysis
Creatine - metabolism
Hippocampus - physiopathology
Humans
Image Interpretation, Computer-Assisted
Magnetic Resonance Spectroscopy
Medical imaging
Neurochemistry
Neuropsychology
Personality disorders
Psychiatry
Reference Values
Turkey
Young Adult
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Summary:In neuroimaging on borderline personality disorder, prior studies focused on the hippocampus and amygdala, as mentioned above. However, no study investigated whether there were neurochemical changes in the patients with borderline personality disorder. Therefore, in the present study, we aimed to investigate neurochemical change of patients diagnosed with borderline disorder and hypothesized that neurochemicals would change in the hippocampus region of these patients. Seventeen patients and the same number of healthy control subjects were analyzed by using a 1.5 Tesla GE Signa Imaging System. N-acetylaspartate (NAA), choline compounds (CHO), and creatine (CRE) values of hippocampal region were measured. The mean NAA/CRE ratio in the hippocampus region was significantly reduced in the patients with borderline personality disorder compared to that of healthy control subjects, In addition, NAA/CHO ratio of the patients with borderline personality disorder was also significantly reduced when compared to that of healthy subjects. There was no difference in the ratio of CHO/CRE. In summary, we present evidence for reduced NAA in the patients with borderline personality disorder.
ISSN:0091-2174
1541-3527
DOI:10.2190/PM.48.4.f