Liver cancer in Malaysia: Epidemiology and clinical presentation in a multiracial Asian population

• Published in: Journal of digestive diseases 2015-03, Vol.16 (3), p.152-158
• Main Authors: Goh, Khean-Lee, Razlan, Hamizah, Hartono, Juanda Leo, Qua, Choon-Seng, Yoong, Boon-Koon, Koh, Peng-Soon, Abdullah, Basri Johan Jeet
• Format: Article
• Language: English
• Subjects: Aged; alpha-Fetoproteins - metabolism; BCLC staging; Biomarkers, Tumor - blood; Carcinoma, Hepatocellular - diagnosis; Carcinoma, Hepatocellular - ethnology; Carcinoma, Hepatocellular - etiology; Carcinoma, Hepatocellular - secondary; Carcinoma, Hepatocellular - therapy; China - ethnology; Chinese; Epidemiology; Female; Health Surveys; Hepatitis; hepatocelluar carcinoma; Humans; India - ethnology; Indian; Liver cancer; Liver Cirrhosis - ethnology; Liver Neoplasms - diagnosis; Liver Neoplasms - ethnology; Liver Neoplasms - etiology; Liver Neoplasms - therapy; Lung Neoplasms - epidemiology; Lung Neoplasms - secondary; Magnetic Resonance Imaging; Malay; Malaysia - epidemiology; Male; Middle Aged; multiracial Asian population; Neoplasm Staging; Population Surveillance; Tomography, X-Ray Computed
• ISSN: 1751-2972; 1751-2980
• DOI: 10.1111/1751-2980.12223

Objective Hepatocellular carcinoma (HCC) is an important cancer in Malaysia. This study aimed to determine the epidemiological characteristics and clinical presentations of patients in a multiracial population consisting of three major Asian races: Malays, Chinese and Indians. Methods Consecutive patients with HCC were prospectively studied from 2006 to 2009. HCC was diagnosed principally on multiphasic computed tomography and magnetic resonance imaging scans of the liver. The tumor was staged according to the Barcelona Clinic Liver Cancer (BCLC) classification. Results Altogether, 348 patients were diagnosed with HCC. There were 239 (68.7%) Chinese patients, 71 (20.4%) Malays and 38 (10.9%) Indians, with the median age of 62.5 years and the male to female ratio of 3.4:1. The predominant etiology in Malay and Chinese patients was hepatitis B virus infection (>60%) and in Indian patients was alcohol intake (26.3%) and cryptogenic cause (29.0%). Hepatitis C was seen in 18.3% of Malays, but less than 10% in Chinese and Indians. BCLC staging was: Stage A, 120 (34.5%); Stage B, 75 (21.6%); Stage C, 84 (24.1%); and Stage D, 69 (19.8%). A larger proportion of Indian than Chinese and Malays patients (44.7%) presented with stage D disease. Portal vein invasion was noted in 124 patients (35.6%) and extrahepatic metastases in 68 (19.5%). Surgical resection and radiofrequency ablation with curative intent was carried out in >90% of stage A patients and transarterial chemoembolization in 49.3% and 21.4% of stages B and C patients, respectively. Conclusions HCC is most common among Chinese, followed by Malays and Indians in Malaysia. The etiology of HCC shows a peculiar racial pattern.