Genotoxicity and carcinogenicity testing of 1,2-dibromopropane and 1,1,3-tribromopropane in comparison to 1,2-dibromo-3-chloropropane

The activities of 1,2-dibromopropane (DBP) and 1,1,3-tribromopropane (TBP) were studied in seven genotoxicity assays, (i) SOS-induction in E. coli, (ii) DNA repair in primary rat hepatocyte culture, (iii) the Salmonella/microsome assay, (iv) a host-mediated assay using Salmonella, (v) the somatic mu...

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Published in:Cell biology and toxicology 1994-08, Vol.10 (4), p.265-279
Main Authors: BELITSKY, G. A, LYTCHEVA, T. A, MIZGIREV, I. V, KHOVANOVA, E. M, UGNIVENKO, E. G, TANIRBERGENOV, T. B, MALINOVSKAYA, K. I, REVAZOVA, YU. A, INGEL, F. I, BRATSLAVSKY, V. A, TERENTYEV, A. B, SHAPIRO, A. A, KHITROVO, I. A, WILLIAMS, G. M, SAFAEV, R. D, ZHURKOV, V. S, VYSKUBENKO, I. F, SYTSHOVA, L. P, SALAMATOVA, O. G, FELDT, E. G, KHUDOLEY, V. V
Format: Article
Language:English
Subjects:
Animals
Carcinogenicity Tests
Carcinogens - toxicity
Cells, Cultured
Danio rerio
DNA Damage
DNA Repair
Drosophila melanogaster
Escherichia coli
Fishes
Mice
Micronucleus Tests
Mutagenicity Tests
Mutagens - toxicity
Propane - analogs & derivatives
Propane - toxicity
Rats
Salmonella
SOS Response (Genetics)
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Summary:The activities of 1,2-dibromopropane (DBP) and 1,1,3-tribromopropane (TBP) were studied in seven genotoxicity assays, (i) SOS-induction in E. coli, (ii) DNA repair in primary rat hepatocyte culture, (iii) the Salmonella/microsome assay, (iv) a host-mediated assay using Salmonella, (v) the somatic mutation and recombination assay in Drosophila melanogaster, (vi) HGPRT-mutagenesis assay in ARL 18 cells, and (vii) micronucleus formation assay in mouse polychromatophylic erythrocytes (PCE), forestomach (FS), glandular stomach (GS), duodenum (D), jejunum (J), cecum (C) and liver (L). The halopropanes were also tested for tumor formation in the fish Danio rerio. DBP was active in assays (ii), (v), (vii FS) and (vii L). TBP was positive in assays (ii) and (iii), strongly positive in (vii L) and borderline positive in (iv). However, neither DBP nor TBP induced tumors in fish, in contrast to the carcinogenic 1,2-dibromo-3-chloropropane. The genotoxicity and potential carcinogenicity of DBP and TBP in mammals is discussed.
ISSN:0742-2091
1573-6822
DOI:10.1007/bf00756766