Gardenamide A attenuated cell apoptosis induced by serum deprivation insult via the ERK1/2 and PI3K/AKT signaling pathways

Highlights • Gardenamide A (GA) attenuates apoptotic cell death induced by serum deprivation. • GA attenuates the accumulation of intramolecular ROS. • GA increases the phosphorylated levels of Akt. • GA increases the phosphorylated levels of ERK1/2.

Saved in:
Bibliographic Details
Published in:Neuroscience 2015-02, Vol.286, p.242-250
Main Authors: Wang, R, Yang, J, Peng, L, Zhao, J, Mu, N, Huang, J, Lazarovici, P, Chen, H, Zheng, W
Format: Article
Language:English
Subjects:
Akt
Animals
Apoptosis - drug effects
cell apoptosis
Cell Survival - drug effects
Cells, Cultured
ERK1/2
Gardenamide A
Iridoids - chemical synthesis
Iridoids - pharmacology
MAP Kinase Signaling System - drug effects
Neurology
Neurons - drug effects
Neurons - metabolism
Neuroprotective Agents - chemical synthesis
Neuroprotective Agents - pharmacology
PC12 Cells
Phosphatidylinositol 3-Kinases - metabolism
Phosphorylation
Proto-Oncogene Proteins c-akt - metabolism
Rats
Retinal Ganglion Cells
ROS
serum deprivation
Signal Transduction - drug effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • Gardenamide A (GA) attenuates apoptotic cell death induced by serum deprivation. • GA attenuates the accumulation of intramolecular ROS. • GA increases the phosphorylated levels of Akt. • GA increases the phosphorylated levels of ERK1/2.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2014.11.056