Intra-visceral insular cortex 2-arachidonoylglycerol, but not N -arachidonoylethanolamide, suppresses acute nausea-induced conditioned gaping in rats

Highlights • Intra-VIC administration of 2-AG suppressed nausea-induced conditioned gaping in rats. • Intra-VIC administration of anandamide did not suppress conditioned gaping. • The anti-nausea effects of 2-AG were not reversed by CB1 antagonism. • None of these manipulations affected LiCl-induced...

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Bibliographic Details
Published in:Neuroscience 2015-02, Vol.286, p.338-344
Main Authors: Sticht, M.A, Limebeer, C.L, Rafla, B.R, Parker, L.A
Format: Article
Language:English
Subjects:
2-arachidonoylglycerol
anandamide
Animals
Antiemetics - pharmacology
Arachidonic Acids - pharmacology
Cannabinoid Receptor Agonists - pharmacology
Cerebral Cortex - drug effects
Cerebral Cortex - physiopathology
endocannabinoid
Endocannabinoids - pharmacology
gape
Glycerides - pharmacology
Lithium Chloride
Male
Nausea - chemically induced
Nausea - physiopathology
Neurology
Polyunsaturated Alkamides - pharmacology
rat
Rats
Rats, Sprague-Dawley
visceral insular cortex
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Summary:Highlights • Intra-VIC administration of 2-AG suppressed nausea-induced conditioned gaping in rats. • Intra-VIC administration of anandamide did not suppress conditioned gaping. • The anti-nausea effects of 2-AG were not reversed by CB1 antagonism. • None of these manipulations affected LiCl-induced taste avoidance.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2014.11.058