Effects of ouabain on respiratory rhythm generation in brainstem-spinal cord preparation from newborn rats and in decerebrate and arterially perfused in situ preparation from juvenile rats

Highlights • The significance of Na/K-ATPase on respiratory rhythm generation was studied. • We examined the effects of ouabain on respiratory activity in newborn and juvenile rats. • Ouabain induced long-lasting facilitation of respiratory rhythm. • Genes encoding Na/K-ATPase α subunit were express...

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Bibliographic Details
Published in:Neuroscience 2015-02, Vol.286, p.404-411
Main Authors: Tsuzawa, K, Yazawa, I, Shakuo, T, Ikeda, K, Kawakami, K, Onimaru, H
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Enzyme Inhibitors - pharmacology
Medulla Oblongata - drug effects
Medulla Oblongata - metabolism
Medulla Oblongata - physiology
Na/K-ATPase
Neurology
Neurons - drug effects
Neurons - physiology
ouabain
Ouabain - pharmacology
Rats
Rats, Wistar
Respiration - drug effects
respiratory rhythm
Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors
Sodium-Potassium-Exchanging ATPase - metabolism
Sodium-Potassium-Exchanging ATPase - physiology
Spinal Cord - physiology
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Summary:Highlights • The significance of Na/K-ATPase on respiratory rhythm generation was studied. • We examined the effects of ouabain on respiratory activity in newborn and juvenile rats. • Ouabain induced long-lasting facilitation of respiratory rhythm. • Genes encoding Na/K-ATPase α subunit were expressed in the ventral medulla. • Na/K-ATPase activity could be an important factor in respiratory rhythm modulation.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2014.12.006