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Effects of ouabain on respiratory rhythm generation in brainstem-spinal cord preparation from newborn rats and in decerebrate and arterially perfused in situ preparation from juvenile rats

Highlights • The significance of Na/K-ATPase on respiratory rhythm generation was studied. • We examined the effects of ouabain on respiratory activity in newborn and juvenile rats. • Ouabain induced long-lasting facilitation of respiratory rhythm. • Genes encoding Na/K-ATPase α subunit were express...

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Published in:	Neuroscience 2015-02, Vol.286, p.404-411
Main Authors:	Tsuzawa, K, Yazawa, I, Shakuo, T, Ikeda, K, Kawakami, K, Onimaru, H
Format:	Article
Language:	English
Subjects:	Animals Animals, Newborn Enzyme Inhibitors - pharmacology Medulla Oblongata - drug effects Medulla Oblongata - metabolism Medulla Oblongata - physiology Na/K-ATPase Neurology Neurons - drug effects Neurons - physiology ouabain Ouabain - pharmacology Rats Rats, Wistar Respiration - drug effects respiratory rhythm Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors Sodium-Potassium-Exchanging ATPase - metabolism Sodium-Potassium-Exchanging ATPase - physiology Spinal Cord - physiology
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description	Highlights • The significance of Na/K-ATPase on respiratory rhythm generation was studied. • We examined the effects of ouabain on respiratory activity in newborn and juvenile rats. • Ouabain induced long-lasting facilitation of respiratory rhythm. • Genes encoding Na/K-ATPase α subunit were expressed in the ventral medulla. • Na/K-ATPase activity could be an important factor in respiratory rhythm modulation.
doi_str_mv	10.1016/j.neuroscience.2014.12.006
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subjects	Animals Animals, Newborn Enzyme Inhibitors - pharmacology Medulla Oblongata - drug effects Medulla Oblongata - metabolism Medulla Oblongata - physiology Na/K-ATPase Neurology Neurons - drug effects Neurons - physiology ouabain Ouabain - pharmacology Rats Rats, Wistar Respiration - drug effects respiratory rhythm Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors Sodium-Potassium-Exchanging ATPase - metabolism Sodium-Potassium-Exchanging ATPase - physiology Spinal Cord - physiology
title	Effects of ouabain on respiratory rhythm generation in brainstem-spinal cord preparation from newborn rats and in decerebrate and arterially perfused in situ preparation from juvenile rats
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