Model Selection Emphasises the Importance of Non-Chromosomal Information in Genetic Studies: e0117014

Ever since the case of the missing heritability was highlighted some years ago, scientists have been investigating various possible explanations for the issue. However, none of these explanations include non-chromosomal genetic information. Here we describe explicitly how chromosomal and non-chromos...

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Bibliographic Details
Published in:PloS one 2015-01, Vol.10 (1)
Main Authors: Rawi, Reda, Anbari, Mohamed El, Bensmail, Halima
Format: Article
Language:English
Online Access:Get full text
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Summary:Ever since the case of the missing heritability was highlighted some years ago, scientists have been investigating various possible explanations for the issue. However, none of these explanations include non-chromosomal genetic information. Here we describe explicitly how chromosomal and non-chromosomal modifiers collectively influence the heritability of a trait, in this case, the growth rate of yeast. Our results show that the non-chromosomal contribution can be large, adding another dimension to the estimation of heritability. We also discovered, combining the strength of LASSO with model selection, that the interaction of chromosomal and non-chromosomal information is essential in describing phenotypes.
ISSN:1932-6203
DOI:10.1371/journal.pone.0117014