Zinc mediated allylations of chlorosilanes promoted by ultrasound: synthesis of novel constrained sila amino acids

A simple, fast and efficient method for allylation and propargylation of chlorosilanes through zinc mediation and ultrasound promotion is reported. As a direct application of the resulting bis-allylsilanes, three novel, constrained sila amino acids are prepared for the first time. The design and syn...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2014-06, Vol.12 (24), p.4093-4097
Main Authors: Ramesh, Remya, Reddy, D Srinivasa
Format: Article
Language:English
Subjects:
Amino Acids - chemical synthesis
Amino Acids - chemistry
gamma-Aminobutyric Acid - analogs & derivatives
gamma-Aminobutyric Acid - chemical synthesis
Silanes - chemical synthesis
Silanes - chemistry
Silicon - chemistry
Ultrasonics - methods
Zinc - chemistry
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Summary:A simple, fast and efficient method for allylation and propargylation of chlorosilanes through zinc mediation and ultrasound promotion is reported. As a direct application of the resulting bis-allylsilanes, three novel, constrained sila amino acids are prepared for the first time. The design and synthesis of the constrained sila analogue of GABA (γ-amino butyric acid) is a highlight of this work.
ISSN:1477-0520
1477-0539
DOI:10.1039/c4ob00294f