Clostridium difficile increases the risk for venous thromboembolism

Abstract Background Inflammatory bowel disease is associated with a higher risk for venous thromboembolism (VTE). Whether Clostridium difficile infection similarly increases this risk is unknown. Methods This was a retrospective analysis of patients admitted to the surgical intensive care unit (ICU)...

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Published in:The American journal of surgery 2014-11, Vol.208 (5), p.703-709
Main Authors: Barmparas, Galinos, M.D, Fierro, Nicole, B.S, Lamb, Alexander W., B.S, Lee, Debora, B.S, Nguyen, Brandon, B.S, Tran, Daniel H., B.S, Chung, Rex, M.D, Ley, Eric J., M.D
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
C. difficile
Case-Control Studies
Clostridium difficile
Clostridium difficile - isolation & purification
Clostridium Infections - complications
Clostridium Infections - diagnosis
Colitis
Critical Care
Deep venous thrombosis
Female
Humans
Logistic Models
Male
Middle Aged
Odds Ratio
Pulmonary embolus
Retrospective Studies
Risk Factors
Surgery
Venous thromboembolism
Venous Thromboembolism - etiology
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Summary:Abstract Background Inflammatory bowel disease is associated with a higher risk for venous thromboembolism (VTE). Whether Clostridium difficile infection similarly increases this risk is unknown. Methods This was a retrospective analysis of patients admitted to the surgical intensive care unit (ICU) at the Cedars-Sinai Medical Center from February 2011 to July 2013. The 2 groups were compared using standard statistical methodology. Results During the 30-month study period, a total of 1,728 patients were admitted to the surgical ICU. A total of 64 patients (3.7%) tested positive for C. difficile . The use of chemical prophylaxis for VTE was significantly higher in the C. difficile group (64.1% vs 46.2%, P = .005). Nonetheless, C. difficile patients had a higher risk for development of a VTE (23.4% vs 11.0%, adjusted odds ratio [95% confidence interval]: 1.87 [1.01 to 3.48], P = .048). In a forward logistic regression model, C. difficile was found to be independently associated with the development of VTE (adjusted odds ratio [95% confidence interval]: 1.87 [1.00 to 3.47], P = .049). Conclusions C. difficile infection increases the risk for VTE in surgical patients admitted to the ICU.
ISSN:0002-9610
1879-1883
DOI:10.1016/j.amjsurg.2014.05.025