The Utility of the Platelet–Lymphocyte Ratio for Predicting No Reflow in Patients With ST-Segment Elevation Myocardial Infarction

The aim of the study was to evaluate the utility of the preprocedural platelet–lymphocyte ratio (PLR) for predicting no reflow in patients undergoing primary percutaneous intervention (PCI) for the treatment of ST-segment elevation myocardial infarction. The thrombolysis in myocardial infarction (TI...

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Bibliographic Details
Published in:Clinical and applied thrombosis/hemostasis 2015-04, Vol.21 (3), p.223-228
Main Authors: Yildiz, Abdulkadir, Yuksel, Murat, Oylumlu, Mustafa, Polat, Nihat, Akyuz, Abdurrahman, Acet, Halit, Aydin, Mesut, Ülgen, Mehmet Siddik
Format: Article
Language:English
Subjects:
Aged
Electrocardiography
Female
Heart attacks
Humans
Lymphocyte Count
Lymphocytes
Male
Middle Aged
No-Reflow Phenomenon - blood
No-Reflow Phenomenon - surgery
Percutaneous Coronary Intervention
Platelet Count
Retrospective Studies
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Summary:The aim of the study was to evaluate the utility of the preprocedural platelet–lymphocyte ratio (PLR) for predicting no reflow in patients undergoing primary percutaneous intervention (PCI) for the treatment of ST-segment elevation myocardial infarction. The thrombolysis in myocardial infarction (TIMI) flow grades of 287 patients treated with primary PCI were assessed retrospectively. Patients were divided into 3 tertiles based upon preprocedural PLR. Pre- and postprocedural TIMI flow grades were evaluated. No reflow developed in 6, 14, and 43 patients in the lower, middle, and higher tertiles, respectively (P < .001). After multivariate analysis, PLR remained a significant predictor of no reflow together with neutrophil–lymphocyte ratio (NLR). A cutoff value of 160 for PLR and 5.9 for NLR predicted no reflow with sensitivities and specificities of 75% and 71% and 74% and 70%, respectively. In conclusion, high preprocedural PLR and NLR levels are significant and independent predictors of no reflow in patients undergoing primary PCI.
ISSN:1076-0296
1938-2723
DOI:10.1177/1076029613519851