Expression of CD64 on neutrophils can be used to predict the severity of bloodstream infection before broad range 16S rRNA PCR

The aging population and increased incidence of severe bacterial infection can lead to sepsis. Interest to early identification of endangered patients and identification of pathogen do not always confirm the infection. To use biomarkers can help in early identification of infection and opportunity t...

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Bibliographic Details
Published in:Folia microbiologica 2015-03, Vol.60 (2), p.111-118
Main Authors: Stubljar, David, Skvarc, Miha
Format: Article
Language:English
Subjects:
Applied Microbiology
Bacteremia - diagnosis
Bacteria - genetics
Bacteria - isolation & purification
Bacterial diseases
Biomarkers - analysis
Biomedical and Life Sciences
Blood
Blood vessels
Diagnostic Tests, Routine - methods
DNA, Bacterial - genetics
DNA, Ribosomal - chemistry
DNA, Ribosomal - genetics
Drug therapy
Environmental Engineering/Biotechnology
Gene expression
Humans
Immunology
Infections
Life Sciences
Microbiology
Neutrophils - chemistry
Polymerase Chain Reaction
Receptors, IgG - analysis
Ribonucleic acid
RNA
RNA, Ribosomal, 16S - genetics
ROC Curve
Severity of Illness Index
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Summary:The aging population and increased incidence of severe bacterial infection can lead to sepsis. Interest to early identification of endangered patients and identification of pathogen do not always confirm the infection. To use biomarkers can help in early identification of infection and opportunity to start therapy timeously. All biomarkers were defined in 33 out of 96 patients. Thirty-two (97 %) patients had bacterial infection and 1 (3 %) patient had systemic inflammatory response syndrome (SIRS) without infection. PCR confirmed the infection in 27 cases and blood cultures in 8. Area under curve (AUC) for CD64 was 1.00, meanwhile other biomarkers showed 2-fold smaller AUC for positive infection. CD64 index was associated with bacterial infection ( p  
ISSN:0015-5632
1874-9356
DOI:10.1007/s12223-014-0346-y