White Blood Cell Counts, Leukocyte Ratios, and Eosinophils as Inflammatory Markers in Patients With Coronary Artery Disease

Inflammation is a key feature of atherosclerosis and its clinical manifestations. The leukocyte count has emerged as a marker of inflammation that is widely available in clinical practice. Since inflammation plays a key role in atherosclerosis and its end results, discovering new biomarkers of infla...

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Bibliographic Details
Published in:Clinical and applied thrombosis/hemostasis 2015-03, Vol.21 (2), p.139-143
Main Authors: Kounis, Nicholas G., Soufras, George D., Tsigkas, Grigorios, Hahalis, George
Format: Article
Language:English
Subjects:
Atherosclerosis
Biomarkers
Biomarkers - blood
Cardiovascular disease
Coronary Artery Disease - blood
Coronary Artery Disease - pathology
Coronary Artery Disease - therapy
Coronary vessels
Disease prevention
Eosinophils - metabolism
Eosinophils - pathology
Humans
Hypersensitivity - blood
Hypersensitivity - pathology
Hypersensitivity - therapy
Inflammation
Inflammation Mediators - blood
Leukocyte Count
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Summary:Inflammation is a key feature of atherosclerosis and its clinical manifestations. The leukocyte count has emerged as a marker of inflammation that is widely available in clinical practice. Since inflammation plays a key role in atherosclerosis and its end results, discovering new biomarkers of inflammation becomes important in order to help diagnostic accuracy and provide prognostic information about coronary cardiac disease. In acute coronary syndromes and percutaneous coronary intervention, elevated levels of almost all subtypes of white blood cell counts, including eosinophils, monocytes, neutrophils, and lymphocytes, and neutrophil–lymphocyte ratio and eosinophil–leukocyte ratio constitute independent predictors of adverse outcomes. Eosinophil count and eosinophil–leukocyte ratio, in particular, emerge as novel biomarkers for risk stratification in patients with coronary artery disease. Since the presence of eosinophils denotes hypersensitivity inflammation and hypersensitivity associated with Kounis syndrome, this reality is essential for elucidating the etiology of inflammation in order to consider predictive and preventive measures and to apply the appropriate therapeutic methods.
ISSN:1076-0296
1938-2723
DOI:10.1177/1076029614531449